Basal Ganglia ‘Loops’ with the Cerebral Cortex
Basal Ganglia ‘Loops’ with the Cerebral Cortex
复制标题
基底神经节与大脑皮层“循环”
DOI：
10.1007/978-4-431-68547-0_7
复制
发表时间：
1995
影响因子：
2
通讯作者：
H. Mushiake
中科院分区：
文献类型：
--
作者：
P. Strick;R. Dum;H. Mushiake
在这一章中，我们提出了一些最新的结果组织的基底神经节“环”与额叶皮质区。我们的研究结果表明，初级运动皮层（M1），补充运动区（SMA）和腹侧运动前区（PMV）的每一个项目最密集的地形不同的区域的尾状核/壳核。这种解剖结构在纹状体中产生了多个“输入通道”。同样地，这些皮质区中的每一个似乎都受到来自苍白球（GPi）内部部分的地形上不同的区域的投影的影响。这种安排在GPi中创建了多个“输出通道”。GPi还包含一个单独的输出通道，投射到前额皮质的46区。因此，基底神经节的输出不限于单个运动区域，而是支配额叶中的多个运动和非运动区域。我们的生理结果表明，各个输出通道与行为的不同方面有关。某些通道，例如投射到M1的通道，可能涉及特定运动参数的控制。其他输出通道，如支配SMA的输出通道，可能与运动行为的高阶方面有关，如基于内部线索产生运动。基底神经节内的连接倾向于将与特定皮质区域相关的输入通道与支配相同皮质区域的输出通道链接起来。这些观察使我们提出，基底神经节与大脑皮层的骨骼运动区相互作用的基础结构框架是多个“闭环”。
In this chapter, we present some recent results on the organization of basal ganglia ‘loops’ with cortical areas in the frontal lobe. Our findings suggest that the primary motor cortex (M1), the supplementary motor area (SMA) and the ventral premotor area (PMv) each project most densely to a topographically distinct region of the caudate/putamen. This anatomical arrangement creates multiple “input channels” in the striatum. Similarly, each of these cortical areas appears to be influenced by projections from a topographically distinct region of the internal segment of the globus pallidus (GPi). This arrangement creates multiple “output channels” in GPi. GPi also contains a separate output channel that projects to area 46 in prefrontal cortex. Thus, the output of the basal ganglia is not limited to a single motor area, but innervates multiple motor and non-motor regions in the frontal lobe. Our physiological results suggest that individual output channels are concerned with different aspects of behavior. Some channels, such as the one projecting to M1, may be involved in the control of specific movement parameters. Other output channels, such as the one that innervates the SMA, may be concerned with higher order aspects of motor behavior like the generation of movement based on internal cues. Connections within the basal ganglia tend to link the input channel related to a particular cortical area with the output channel that innervates the same cortical area. These observations lead us to propose that the underlying structural framework for basal ganglia interactions with the skeletomotor areas of the cerebral cortex is multiple “closed loops”.
登录
查看更多内容
影响因子：
2.5
作者：
J. Mink;W. T. Thach
通讯作者：
J. Mink;W. T. Thach
影响因子：
2.5
作者：
ANDERSON, ME;HORAK, FB
通讯作者：
HORAK, FB
影响因子：
56.9
作者：
MIDDLETON, FA;STRICK, PL
通讯作者：
STRICK, PL
影响因子：
2.5
作者：
DELONG, MR;CRUTCHER, MD;GEORGOPOULOS, AP
通讯作者：
GEORGOPOULOS, AP
影响因子：
56.9
作者：
HOOVER, JE;STRICK, PL
通讯作者：
STRICK, PL