Chronic and acute stress, gender, and serotonin transporter gene-environment interactions predicting depression symptoms in youth.
Chronic and acute stress, gender, and serotonin transporter gene-environment interactions predicting depression symptoms in youth.
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DOI：
10.1111/j.1469-7610.2009.02177.x
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发表时间：
2010-02
期刊：
影响因子：
--
通讯作者：
Najman JM
中科院分区：
文献类型：
--
作者：
Hammen C;Brennan PA;Keenan-Miller D;Hazel NA;Najman JM
最近通过环境影响预测抑郁症的许多关于5-羟色胺转运体基因的研究都使用了未定义的或糟糕的心理测量学方法的压力评估，这可能导致了结果的巨大差异。本研究试图区分急性应激和慢性应激对20岁时抑郁症状的预测作用，研究对象为346名在15岁至20岁时5HTT基因多态性不同的青年。访谈方法评估了15岁至19岁之间的重大急性生活事件，对15岁时青年及其父母的多次访谈和问卷调查提供了慢性家庭压力的指标。Lg等位基因被重新分类为S。15岁时的慢性家庭压力预示着具有一个或两个S等位基因的人在20岁时抑郁得分更高，并且遗传调节的影响仅对女性显著。基因-环境交互作用对急性应激无显著影响。在压力-抑郁关联机制的研究中，鼓励对慢性和急性压力以及性别的影响进行仔细的测量和分离。
Many recent studies of serotonin transporter gene by environment effects predicting depression have used stress assessments with undefined or poor psychometric methods, possibly contributing to wide variation in findings. The present study attempted to distinguish between effects of acute and chronic stress to predict depressive symptoms at age 20 among 346 youth varying in polymorphisms of the 5HTT gene who had been assessed at ages 15 and 20. Interview measures assessed major acute life events between 15 and 19, and multiple interviews and questionnaires with youths and their parents at youth age 15 provided an index of chronic family stress. Lg alleles were reclassified as S. Chronic family stress at age 15 predicted higher depression scores at 20 among those with one or two S alleles, and the effects of genetic moderation were significant only for females. Gene-environment interactions with acute stress were nonsignificant. Careful measurement and separation of the effects of chronic and acute stress, and gender, are encouraged in the study of mechanisms of the stress-depression association.
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影响因子：
6.9
作者：
Hazel, N. A.;Hammen, C.;Najman, J.
通讯作者：
Najman, J.
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0.9
作者：
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影响因子：
3.6
作者：
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作者：
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通讯作者：
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影响因子：
10.6
作者：
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通讯作者：
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