Results of radical radiotherapy for squamous cell carcinoma of the eyelid.
Results of radical radiotherapy for squamous cell carcinoma of the eyelid.
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DOI：
10.1093/jrr/rrt069
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发表时间：
2013-11-01
影响因子：
2
通讯作者：
Itami J
中科院分区：
文献类型：
--
作者：
Inaba K;Ito Y;Suzuki S;Sekii S;Takahashi K;Kuroda Y;Murakami N;Morota M;Mayahara H;Sumi M;Uno T;Itami J
目的：目的分析眼睑鳞状细胞癌电子束根治性放疗的疗效，探讨影响预后的因素。材料与方法：回顾性分析了1964年至2010年期间在我们机构接受电子束放射治疗的38例组织学证实的眼睑SCC患者的记录。中位肿瘤大小为15 mm（范围：3-40 mm）。T1期3例，T2 a期6例，T2 b期14例，T3 a期15例。4例有淋巴结转移。在38例患者中，14例在既往治疗后复发。中位放射剂量为60.0戈伊（范围45.0-70.4戈伊）。中位随访时间为72.5个月（范围：2.0-369个月）。结果如下：5年局部无复发率为71.8%，淋巴结无复发率为77.5%，远处无转移率为90.6%，无复发率为58.0%。7例患者的11个面颈部出现淋巴结转移。5年总生存率为79.5%。T分期和以EQD 2戈伊表示的辐射剂量倾向于影响局部控制。复发患者的局部无复发率较差，但无统计学意义。在死亡的14名患者中，12名死于并发症。在9例患者中观察到3级或以上重度晚期发病率（CTCAE ver4.0）。由于发病，两名患者失去了视力。结论：眼睑鳞状细胞癌的根治性放射治疗取得了良好的效果，可以作为一种治疗选择。放疗剂量递增能否提高晚期T分期和复发患者的局部控制率，有待进一步研究。
Purpose: To analyze the results of radical radiotherapy by electron beams for squamous cell carcinoma (SCC) of the eyelid and to find the possible prognostic factors. Materials and Methods: Records of 38 patients with histologically confirmed SCC of the eyelid who underwent electron beam radiation therapy between 1964 and 2010 in our institution were retrospectively reviewed. Median tumor size was 15 mm (range, 3–40 mm). T stage was T1 in three, T2a in six, T2b in 14, and T3a in 15 patients. Four patients had nodal metastasis. Of the 38 patients, 14 had relapsed disease after prior treatment. Median radiation dose was 60.0 Gy (range, 45.0–70.4 Gy). Median follow-up was 72.5 months (range, 2.0–369 months). Results: 5-year local relapse-free, nodal relapse-free, distant metastasis-free and relapse-free rates for all patients were 71.8%, 77.5%, 90.6% and 58.0%, respectively. In seven patients, lymph node metastases occurred in 11 faciocervical regions. The 5-year overall survival was 79.5%. T stage and radiation dose expressed in EQD2 Gy tended to have impacts on local control. Relapsed patients showed unfavorable local relapse-free rate, however this was without statistical significance. Of the 14 patients who died, 12 succumbed to concurrent diseases. Grade 3 or greater severe late morbidities (CTCAE ver4.0) were observed in nine patients. Due to the morbidities, two patients lost their vision. Conclusion: Radical radiotherapy for SCC of the eyelid yielded good results and could be a treatment option. Whether radiation-dose escalation could improve local control in advanced T stages and relapsed patients needs further study.
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影响因子：
13.7
作者：
Cook, BE;Bartley, GB
通讯作者：
Bartley, GB
DOI：
10.1016/0360-3016(84)90023-3
发表时间：
1984-01-01
影响因子：
7
作者：
FITZPATRICK, PJ;THOMPSON, GA;PAYNE, DG
通讯作者：
PAYNE, DG
影响因子：
4.1
作者：
Donaldson, MJ;Sullivan, TJ;Williamson, RM
通讯作者：
Williamson, RM
影响因子：
4.1
作者：
LEDERMAN, M
通讯作者：
LEDERMAN, M
影响因子：
6.2
作者：
Petsuksiri, Janjira;Frank, Steven J.;Esmaeli, Bita
通讯作者：
Esmaeli, Bita