Adolescent brain development and depression: A case for the importance of connectivity of the anterior cingulate cortex.
Adolescent brain development and depression: A case for the importance of connectivity of the anterior cingulate cortex.
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DOI:
10.1016/j.neubiorev.2016.07.024
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发表时间:
2016-11
影响因子:
8.2
通讯作者:
Forbes, Erika E.
中科院分区:
文献类型:
--
作者:
Lichenstein, Sarah D.;Verstynen, Timothy;Forbes, Erika E.
We propose that structural and functional connectivity of the anterior cingulate cortex (ACC) represents a critical component of adolescent developmental psychopathology. We hypothesize that connectivity of the ACC, a hub for integrating cognitive, affective, and social information to guide self-regulation across domains, supports adaptive development of self-regulation during adolescence and that, conversely, disrupted maturation of ACC connectivity contributes to the development of depression. To integrate findings on typical development, we report results of a meta-analysis of diffusion imaging findings of typical adolescent development of the cingulum and anterior thalamic radiation, the tracts most relevant to ACC connectivity, and provide a critical review of the literature on ACC functional connectivity. Finally, we review the evidence for altered structural and functional connectivity in adolescents with depression. Although the evidence for our claim is persuasive, a more comprehensive understanding of the ACC’s role depends upon future investigations with sophisticated modeling of networks, prospective and longitudinal designs, and examination of structure-function associations.
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