Adolescent brain development and depression: A case for the importance of connectivity of the anterior cingulate cortex.

Adolescent brain development and depression: A case for the importance of connectivity of the anterior cingulate cortex.
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DOI:
10.1016/j.neubiorev.2016.07.024
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发表时间:
2016-11
影响因子:
8.2
通讯作者:
Forbes, Erika E.
Forbes, Erika E.
中科院分区:
医学1区
文献类型:
--
作者:
Lichenstein, Sarah D.;Verstynen, Timothy;Forbes, Erika E.

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我们认为,前扣带皮层(ACC)的结构和功能连接是青少年发展性精神病理学的一个重要组成部分。我们假设前扣带皮层的连通性是一个整合认知、情感和社会信息以指导跨领域自我调节的枢纽,支持青春期自我调节的适应性发展,相反,前扣带皮层连接成熟的中断有助于抑郁症的发展。为了整合典型发育的研究结果,我们报告了典型青少年扣带和丘脑前辐射(与ACC连通性最相关的束)扩散成像结果的荟萃分析结果,并对ACC功能连通性的文献进行了批判性回顾。最后,我们回顾了抑郁症青少年结构和功能连接改变的证据。尽管我们的观点的证据是有说服力的,但更全面地了解ACC的作用取决于未来的研究,包括复杂的网络模型,前瞻性和纵向设计,以及结构-功能关联的检查。
We propose that structural and functional connectivity of the anterior cingulate cortex (ACC) represents a critical component of adolescent developmental psychopathology. We hypothesize that connectivity of the ACC, a hub for integrating cognitive, affective, and social information to guide self-regulation across domains, supports adaptive development of self-regulation during adolescence and that, conversely, disrupted maturation of ACC connectivity contributes to the development of depression. To integrate findings on typical development, we report results of a meta-analysis of diffusion imaging findings of typical adolescent development of the cingulum and anterior thalamic radiation, the tracts most relevant to ACC connectivity, and provide a critical review of the literature on ACC functional connectivity. Finally, we review the evidence for altered structural and functional connectivity in adolescents with depression. Although the evidence for our claim is persuasive, a more comprehensive understanding of the ACC’s role depends upon future investigations with sophisticated modeling of networks, prospective and longitudinal designs, and examination of structure-function associations.
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