Hepatitis B virus infection and B-cell non-Hodgkin's lymphoma in a hepatitis B endemic area: a case-control study.
Hepatitis B virus infection and B-cell non-Hodgkin's lymphoma in a hepatitis B endemic area: a case-control study.
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DOI：
10.1111/j.1349-7006.2002.tb01280.x
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发表时间：
2002-05
期刊：
影响因子：
--
通讯作者：
Kim NK
中科院分区：
文献类型：
--
作者：
Kim JH;Bang YJ;Park BJ;Yoo T;Kim CW;Kim TY;Heo DS;Lee HS;Kim NK
多项研究报道 B 细胞非霍奇金淋巴瘤患者慢性丙型肝炎病毒 (HCV) 感染的患病率较高，并提示 HCV 具有致病作用，但关于乙型肝炎病毒 (HBV) 感染和非霍奇金淋巴瘤的研究有限。为了确定乙型肝炎病毒感染与非霍奇金淋巴瘤之间的关联，我们在乙型肝炎流行区韩国进行了一项病例对照研究。我们招募了1997年1月至1998年12月期间在首尔国立大学医院新诊断为非霍奇金淋巴瘤的222名患者作为病例。每个病例选择 4 名年龄和性别匹配的对照，对照组包括 439 名非血液恶性肿瘤患者（对照组 1）和 444 名非恶性疾病受试者（对照组 2）。在控制了淋巴瘤的其他潜在危险因素（例如吸烟、饮酒、输血史和丙型肝炎病毒感染）后，计算了乙型肝炎表面抗原检测呈阳性的个体患非霍奇金淋巴瘤的相对风险。 222 名非霍奇金淋巴瘤患者中有 28 名（12.6%）乙型肝炎表面抗原呈阳性，而对照组 1 的 439 名患者中有 32 名（7.3%）乙型肝炎表面抗原呈阳性，对照组 2 的 444 名患者中有 21 名（4.7%）乙型肝炎表面抗原呈阳性（P=0.001）。通过多变量分析，HBV 携带者中 B 细胞非霍奇金淋巴瘤的粗比值比为 2.54（1.46-4.45），调整后的比值比为 3.30（1.69-6.45）。本研究表明，乙型肝炎病毒携带者患 B 细胞非霍奇金淋巴瘤的风险增加，值得进一步研究乙型肝炎病毒在 B 细胞非霍奇金淋巴瘤发病机制中的可能作用。
Several studies have reported a higher prevalence of chronic hepatitis C virus (HCV) infection in patients with B‐cell non‐Hodgkin's lymphoma and suggested a pathogenic role for HCV, but studies on hepatitis B virus (HBV) infection and non‐Hodgkin's lymphoma are limited. To determine the association between HBV infection and non‐Hodgkin's lymphoma, we performed a case‐control study in Korea, a hepatitis B endemic area. We recruited 222 patients newly diagnosed with non‐Hodgkin's lymphoma at Seoul National University Hospital between January 1997 and December 1998 as cases. Four age‐ and sex‐matched controls were selected for each case, and the control groups comprised of 439 patients with non‐hematological malignancy (control group 1) and 444 subjects with non‐malignant conditions (control group 2). Relative risk of developing non‐Hodgkin's lymphoma among individuals tested positive for hepatitis B surface antigen was calculated after controlling for other potential risk factors of lymphoma, such as smoking, alcohol drinking, transfusion history and HCV infection. Hepatitis B surface antigen was positive in 28 of 222 patients (12.6%) with non‐Hodgkin's lymphoma compared with 32 of 439 (7.3%) in control group 1, and 21 of 444 (4.7%) in control group 2 (P=0.001). The crude odds ratio for B‐cell non‐Hodgkin's lymphoma among the HBV carriers was 2.54 (1.46–4.45) and the adjusted odds ratio was 3.30 (1.69–6.45) by multivariate analysis. The present study suggests that the risk of B‐cell non‐Hodgkin's lymphoma is increased in HBV carriers and warrants further investigation of the possible role of hepatitis B virus in the pathogenesis of B‐cell non‐Hodgkin's lymphoma.
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影响因子：
5.4
作者：
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作者：
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DOI：
10.1046/j.1440-1746.2001.02406.x
发表时间：
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