An FMRI study of the influence of a history of substance abuse on working memory-related brain activation in schizophrenia.
An FMRI study of the influence of a history of substance abuse on working memory-related brain activation in schizophrenia.
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DOI：
10.3389/fpsyt.2014.00001
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发表时间：
2014
影响因子：
4.7
通讯作者：
Barch DM
中科院分区：
文献类型：
--
作者：
Wojtalik JA;Barch DM
关于过去的药物滥用（SA）对精神分裂症患者工作记忆（WM）损伤的影响几乎没有研究。本研究考察了精神分裂症患者过去的 SA（6 个月或更长的禁欲期）对 WM 的行为和神经生物学影响。 37 名精神分裂症患者（17 名过去有 SA，20 名没有）和 32 名对照者（12 名过去有 SA，20 名没有）在不同日期的 fMRI 扫描期间完成了两个版本的双背 WM 任务。分析的重点是其激活模式在两个 n-back 任务中复制的区域。精神分裂症患者在两项 n-back 任务上的准确度均明显低于对照组。没有观察到与过去的 SA 对 WM 表现的主要影响或相互作用。然而，几个额顶叶丘脑区域显示诊断组和过去的 SA 之间存在相互作用。与没有过去 SA 的对照相比，这些区域在有过去 SA 的对照中显着更活跃。过去有或没有过去 SA 的精神分裂症患者要么没有表现出显着差异，要么过去有 SA 的患者在 WM 期间表现出与没有过去 SA 的患者相比激活程度稍低。这些结果表明，过去的 SA 对对照者的 WM 大脑功能有强大的影响，但过去的 SA 对精神分裂症的影响较小。这与之前的文献一致，表明 SA 精神分裂症患者的神经认知受损较少。
There has been little investigation of the effects of past substance abuse (SA) on working memory (WM) impairments in schizophrenia. This study examined the behavioral and neurobiological impact of past SA (6 months or longer abstinence period) on WM in schizophrenia. Thirty-seven schizophrenia patients (17 with past SA and 20 without) and 32 controls (12 with past SA and 20 without) completed two versions of a two-back WM task during fMRI scanning on separate days. Analyses focused on regions whose patterns of activation replicated across both n-back tasks. Schizophrenia patients were significantly less accurate than controls on both n-back tasks. No main effects or interactions with past SA on WM performance were observed. However, several fronto-parietal-thalamic regions showed an interaction between diagnostic group and past SA. These regions were significantly more active in controls with past SA compared to controls without past SA. Schizophrenia patients with or without past SA either showed no significant differences, or patients with past SA showed somewhat less activation compared to patients without past SA during WM. These results suggest robust effects of past SA on WM brain functioning in controls, but less impact of past SA in schizophrenia. This is consistent with previous literature indicating less impaired neurocognition in schizophrenia with SA.
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DOI：
10.1111/j.1440-0979.2004.00346.x
发表时间：
2004-12-01
影响因子：
5.6
作者：
Herman, Michael
通讯作者：
Herman, Michael
影响因子：
6.7
作者：
Donoghue, K.;Mazzoncini, R.;Doody, G. A.
通讯作者：
Doody, G. A.
影响因子：
5.7
作者：
Desmond, JE;Chen, SHA;Sullivan, EV
通讯作者：
Sullivan, EV
影响因子：
3
作者：
Gur, RC;Sara, R;Gur, RE
通讯作者：
Gur, RE
DOI：
10.1016/s0926-6410(03)00075-2
发表时间：
2003-05-01
期刊：
COGNITIVE BRAIN RESEARCH
影响因子：
--
作者：
Daumann, J;Fimm, B;Gouzoulis-Mayfrank, E
通讯作者：
Gouzoulis-Mayfrank, E