Cognitive Frailty is Associated With Elevated Proinflammatory Markers and a Higher Risk of Mortality.
Cognitive Frailty is Associated With Elevated Proinflammatory Markers and a Higher Risk of Mortality.
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DOI：
10.1016/j.jagp.2022.01.012
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发表时间：
2022-07
影响因子：
7.2
通讯作者：
Castro-Costa, Erico
中科院分区：
文献类型：
--
作者：
Diniz, Breno S.;Lima-Costa, Maria Fernanda;Peixoto, Sergio Viana;Firmo, Joselia O. A.;Torres, Karen C. L.;Martins-Filho, Olindo Assis;Teixeira-Carvalho, Andrea;Grady, James;Kuchel, George A.;Castro-Costa, Erico
认知障碍和身体虚弱在老年人中很常见，并且与不良健康结果的可能性更高有关。这两种情况经常在同一个人中共存为认知功能障碍，但很少有研究探讨这种并发症对临床结果或潜在生物学机制的影响。本研究共纳入了来自班布伊老龄化队列研究的1，340名老年人（年龄≥ 60岁），总随访时间为10年。根据MMSE评分< 22，通过缺陷框架和认知障碍的累积来定义虚弱。此外，通过流式细胞仪微球阵列测定血清IL-6水平。与健全的认知未受损组相比，被归类为认知脆弱的个体具有显著更高的血清IL-6水平。在10年的随访中，认知功能障碍（aOR=1.97 [1.18-3.27]）和前虚弱和认知功能障碍（aOR=1.83 [1.24-2.69]）的死亡风险最高。较高的IL-6水平也与较高的死亡率独立相关（aOR=1.37 [1.23-1.54]）。我们的研究表明，认知脆弱表明一种脆弱的状态和增加的死亡风险。我们的研究结果还表明，促炎性异常可以被视为常见年龄相关问题的核心现象（例如，认知障碍和虚弱）和结果（例如，死亡率）。
Cognitive impairment and physical frailty are common among older adults and associated with a higher likelihood of adverse health outcomes. These two conditions frequently co-exist in the same individual as cognitive frailty, yet few studies have examined the impact of such comorbidity on clinical outcomes or underlying biological mechanisms. A total of 1,340 older adults (age ≥ 60 years old) from the Bambui Cohort Study of Ageing, with a total follow-up of 10 years, were included in this study. Frailty was defined by the accumulation of deficit framework and cognitive impairment based on scores on the MMSE < 22. In addition, serum IL-6 levels were measured by cytometric bead array assay. Individuals classified with cognitive frailty had significantly higher serum IL-6 levels compared to the robust, cognitively unimpaired group. Those with cognitive frailty (aOR=1.97 [1.18–3.27] and pre-frailty and cognitive impairment (aOR=1.83 [1.24–2.69]) had the highest mortality risk over ten years of follow-up. Higher IL-6 levels were also independently associated with a higher mortality rate (aOR=1.37 [1.23–1.54]). Our study shows that cognitive Frailty indicates a vulnerability state and of increasing mortality risk. Our findings also suggested that pro-inflammatory abnormalities can be viewed as a central phenomenon underlying common age-related problems (e.g., cognitive impairment and Frailty) and outcomes (e.g., mortality).
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影响因子：
64.5
作者：
López-Otín C;Blasco MA;Partridge L;Serrano M;Kroemer G
通讯作者：
Kroemer G
DOI：
10.1590/s0102-311x2011001500014
发表时间：
2011-01-01
期刊：
Cadernos de Saúde Pública
影响因子：
--
作者：
Loyola Filho, Antônio Ignácio de;Firmo, Josélia O. A.;Lima-Costa, Maria Fernanda
通讯作者：
Lima-Costa, Maria Fernanda
影响因子：
3.9
作者：
Lima Torres, Karen Cecilia;de Rezende, Vitor Bortolo;Teixeira-Carvalho, Andrea
通讯作者：
Teixeira-Carvalho, Andrea
影响因子：
14
作者：
Thies, William;Bleiler, Laura
通讯作者：
Bleiler, Laura
DOI：
10.1038/s41569-018-0064-2
发表时间：
2018-09
期刊：
Nature reviews. Cardiology
影响因子：
--
作者：
Ferrucci L;Fabbri E
通讯作者：
Fabbri E