Gut microbiota and host genetics modulate the effect of diverse diet patterns on metabolic health.
Gut microbiota and host genetics modulate the effect of diverse diet patterns on metabolic health.
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DOI：
10.3389/fnut.2022.896348
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发表时间：
2022
影响因子：
5
通讯作者：
Bennett, Brian J. J.
中科院分区：
文献类型：
--
作者：
Huda, M. Nazmul;Salvador, Anna C. C.;Barrington, William T. T.;Gacasan, C. Anthony;D'Souza, Edeline M.;Ramirez, Laura Deus;Threadgill, David W. W.;Bennett, Brian J. J.
代谢疾病是世界范围内的主要公共卫生问题，导致医疗费用过高，并增加包括 SARS-CoV-2 感染在内的许多疾病的并发症。西方饮食（WD）被认为是全球代谢疾病流行的主要原因。相比之下，地中海饮食（MeD）、生酮饮食（KD）和日本饮食（JD）通常被认为有益于代谢健康。然而，人们越来越认识到饮食对代谢健康的影响取决于包括宿主遗传学在内的多种因素。此外，代谢健康状况不佳也归因于肠道微生物组成和/或功能的改变。为了了解宿主遗传学、肠道微生物群和饮食模式之间的复杂关系，我们用四种人类相关饮食（MeD、JD、KD、WD）和 6 周至 30 周龄的对照小鼠饲料处理四种广泛使用的代谢多样化近交小鼠品系（A/J、C57BL/6J、FVB/NJ 和 NOD/ShiLtJ）。我们发现饮食引起的肠道微生物群（α-多样性、β-多样性和多种细菌的丰度，包括双歧杆菌、瘤胃球菌、Turicibacter、Faecalibaculum 和 Akkermansia）的改变受到宿主遗传学的显着改变。此外，根据肠道微生物群的不同，相同的饮食可能会对代谢健康产生不同的影响。我们的研究还表明，与本研究中的其他品系相比，C57BL/6J 小鼠更容易受到肠道微生物群改变的影响，这表明宿主遗传学是饮食-微生物群-代谢健康轴的重要调节剂。总体而言，我们的研究证明了宿主遗传学、肠道微生物群和饮食对代谢健康之间复杂的相互作用；表明在开发新的、更有效的精准营养策略以改善代谢健康时需要考虑宿主遗传学和肠道微生物群。
Metabolic diseases are major public health issues worldwide and are responsible for disproportionately higher healthcare costs and increased complications of many diseases including SARS-CoV-2 infection. The Western Diet (WD) specifically is believed to be a major contributor to the global metabolic disease epidemic. In contrast, the Mediterranean diet (MeD), Ketogenic diet (KD), and Japanese diet (JD) are often considered beneficial for metabolic health. Yet, there is a growing appreciation that the effect of diet on metabolic health varies depending on several factors including host genetics. Additionally, poor metabolic health has also been attributed to altered gut microbial composition and/or function. To understand the complex relationship between host genetics, gut microbiota, and dietary patterns, we treated four widely used metabolically diverse inbred mouse strains (A/J, C57BL/6J, FVB/NJ, and NOD/ShiLtJ) with four human-relevant diets (MeD, JD, KD, WD), and a control mouse chow from 6 weeks to 30 weeks of age. We found that diet-induced alteration of gut microbiota (α-diversity, β-diversity, and abundance of several bacteria including Bifidobacterium, Ruminococcus, Turicibacter, Faecalibaculum, and Akkermansia) is significantly modified by host genetics. In addition, depending on the gut microbiota, the same diet could have different metabolic health effects. Our study also revealed that C57BL/6J mice are more susceptible to altered gut microbiota compared to other strains in this study indicating that host genetics is an important modulator of the diet-microbiota-metabolic health axis. Overall, our study demonstrated complex interactions between host genetics, gut microbiota, and diet on metabolic health; indicating the need to consider both host genetics and the gut microbiota in the development of new and more effective precision nutrition strategies to improve metabolic health.
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影响因子：
82.9
作者：
Berry SE;Valdes AM;Drew DA;Asnicar F;Mazidi M;Wolf J;Capdevila J;Hadjigeorgiou G;Davies R;Al Khatib H;Bonnett C;Ganesh S;Bakker E;Hart D;Mangino M;Merino J;Linenberg I;Wyatt P;Ordovas JM;Gardner CD;Delahanty LM;Chan AT;Segata N;Franks PW;Spector TD
通讯作者：
Spector TD
影响因子：
5.3
作者：
Cooper, Michael A.;Menta, Blaise W.;Wright, Douglas E.
通讯作者：
Wright, Douglas E.
影响因子：
12.3
作者：
Hildebrand F;Nguyen TL;Brinkman B;Yunta RG;Cauwe B;Vandenabeele P;Liston A;Raes J
通讯作者：
Raes J
影响因子：
24.5
作者：
Hadizadeh F;Bonfiglio F;Belheouane M;Vallier M;Sauer S;Bang C;Bujanda L;Andreasson A;Agreus L;Engstrand L;Talley NJ;Rafter J;Baines JF;Walter S;Franke A;D'Amato M
通讯作者：
D'Amato M
影响因子：
6.4
作者：
EISENSTEIN, TK;KILLAR, LM;SULTZER, BM
通讯作者：
SULTZER, BM