Emerging Role of miR-345 and Its Effective Delivery as a Potential Therapeutic Candidate in Pancreatic Cancer and Other Cancers.
Emerging Role of miR-345 and Its Effective Delivery as a Potential Therapeutic Candidate in Pancreatic Cancer and Other Cancers.
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miR-345的新作用及其作为胰腺癌和其他癌症潜在治疗候选者的有效递送
DOI：
10.3390/pharmaceutics13121987
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发表时间：
2021-11-23
期刊：
影响因子：
5.4
通讯作者：
Rachagani S
中科院分区：
文献类型：
--
作者：
Natesh NS;White BM;Bennett MMC;Uz M;Kalari Kandy RR;Batra SK;Mallapragada SK;Rachagani S
胰腺导管腺癌(PDAC)是一种恶性侵袭性肿瘤，由于选择性代偿途径和促结缔组织增生反应的快速上调，死亡率高，预后差，只能姑息治疗。MiRNAs是一种小的非编码RNA，最近被发现是调节癌症发病机制的关键因素。失调的miRNAs与肿瘤发生、转移和PDAC以及其他癌症的化疗耐药相关的分子通路有关。改变癌症中miRNA水平的靶向治疗策略在治疗干预方面具有很好的潜力。MiRNA-345(miR-345)在肿瘤抑制中发挥重要作用，在多种肿瘤中差异表达，包括胰腺癌(PC)。我们以前已经研究过miR-345的潜在机制(S)和传递策略。在这里，我们总结了miR-345在不同癌症中的潜在治疗作用，重点是PDAC，对于miRNA药物的发现、开发、现状和意义。此外，我们重点研究了基于不同材料和纳米配方的miRNA纳米递送系统(S)，专门用于递送miR-345。
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with high mortality, poor prognosis, and palliative treatments, due to the rapid upregulation of alternative compensatory pathways and desmoplastic reaction. miRNAs, small non-coding RNAs, have been recently identified as key players regulating cancer pathogenesis. Dysregulated miRNAs are associated with molecular pathways involved in tumor development, metastasis, and chemoresistance in PDAC, as well as other cancers. Targeted treatment strategies that alter miRNA levels in cancers have promising potential as therapeutic interventions. miRNA-345 (miR-345) plays a critical role in tumor suppression and is differentially expressed in various cancers, including pancreatic cancer (PC). The underlying mechanism(s) and delivery strategies of miR-345 have been investigated by us previously. Here, we summarize the potential therapeutic roles of miR-345 in different cancers, with emphasis on PDAC, for miRNA drug discovery, development, status, and implications. Further, we focus on miRNA nanodelivery system(s), based on different materials and nanoformulations, specifically for the delivery of miR-345.
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