Low-Viscosity Polydimethylsiloxane Resin for Facile 3D Printing of Elastomeric Microfluidics.
Low-Viscosity Polydimethylsiloxane Resin for Facile 3D Printing of Elastomeric Microfluidics.
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DOI：
10.3390/mi14040773
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发表时间：
2023-03-30
期刊：
影响因子：
3.4
通讯作者：
Potkay J
中科院分区：
文献类型：
--
作者：
Fleck E;Keck C;Ryszka K;DeNatale E;Potkay J
微流体技术是一种具有广泛应用的快速发展的技术，但受到基于聚二甲基硅氧烷（PDMS）的设备的缓慢、费力的制造技术的限制。目前，3D打印有望通过高分辨率的商业系统来解决这一挑战，但由于缺乏材料进步，无法生成具有微米级特征的高保真零件。为了克服这一限制，低粘度、可光聚合的PDMS树脂与甲基丙烯酸酯-PDMS共聚物、甲基丙烯酸酯-PDMS遥爪聚合物、光吸收剂、苏丹I、光敏剂、2-异丙基噻吨酮和光引发剂2，4，6_三甲基苯甲酰基二苯基氧化膦一起配制。这种树脂的性能在数字光处理（DLP）3D打印机Asiga MAX X27 UV上进行了验证。树脂分辨率，部分保真度，机械性能，透气性，光学透明度和生物相容性进行了研究。这种树脂产生了分辨率高至38.4（±5.0）µm的无障碍通道和薄至30.9（±0.5）µm的膜。打印材料具有58.6% ± 18.8%的断裂伸长率、0.30 ± 0.04MPa的杨氏模量，并且对O2（596 Barrers）和CO2（3071 Barrers）具有高度渗透性。在未反应组分的乙醇提取之后，该材料显示出光学澄清度和透明度（>80%透射率）以及作为体外组织培养基质的活力。本文介绍了一种高分辨率的PDMS 3D打印树脂，用于微流体和生物医学设备的简易制造。
Microfluidics is a rapidly advancing technology with expansive applications but has been restricted by slow, laborious fabrication techniques for polydimethylsiloxane (PDMS)-based devices. Currently, 3D printing promises to address this challenge with high-resolution commercial systems but is limited by a lack of material advances in generating high-fidelity parts with micron-scale features. To overcome this limitation, a low-viscosity, photopolymerizable PDMS resin was formulated with a methacrylate-PDMS copolymer, methacrylate-PDMS telechelic polymer, photoabsorber, Sudan I, photosensitizer, 2-isopropylthioxanthone, and a photoinitiator, 2,4,6-trimethyl benzoyl diphenylphosphine oxide. The performance of this resin was validated on a digital light processing (DLP) 3D printer, an Asiga MAX X27 UV. Resin resolution, part fidelity, mechanical properties, gas permeability, optical transparency, and biocompatibility were investigated. This resin produced resolved, unobstructed channels as small as 38.4 (±5.0) µm tall and membranes as thin as 30.9 (±0.5) µm. The printed material had an elongation at break of 58.6% ± 18.8%, Young’s modulus of 0.30 ± 0.04 MPa, and was highly permeable to O2 (596 Barrers) and CO2 (3071 Barrers). Following the ethanol extraction of the unreacted components, this material demonstrated optical clarity and transparency (>80% transmission) and viability as a substrate for in vitro tissue culture. This paper presents a high-resolution, PDMS 3D-printing resin for the facile fabrication of microfluidic and biomedical devices.
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3.9
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