X-ray-induced shortwave infrared biomedical imaging using rare-earth nanoprobes.

X-ray-induced shortwave infrared biomedical imaging using rare-earth nanoprobes.
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DOI:
10.1021/nl504123r
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发表时间:
2015-01-14
期刊:
影响因子:
10.8
通讯作者:
Xing L
Xing L
中科院分区:
材料科学1区
文献类型:
--
作者:
Naczynski DJ;Sun C;Türkcan S;Jenkins C;Koh AL;Ikeda D;Pratx G;Xing L

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短波红外(SWIR或NIR-II)光由于减少了自发荧光和光子散射,为生物结构成像提供了显著的优势。在这里,我们报告了稀土纳米探测器的发展,它在X射线照射后显示出SWIR发光。我们展示了X射线诱导SWIR发光(X-IR)监测生物分布和绘制淋巴引流图的能力。我们的结果表明,X-IR成像是一种很有前途的临床前应用的新方法,并具有双模式分子疾病成像的潜力。
Shortwave infrared (SWIR or NIR-II) light provides significant advantages for imaging biological structures due to reduced autofluorescence and photon scattering. Here, we report on the development of rare-earth nanoprobes that exhibit SWIR luminescence following X-ray irradiation. We demonstrate the ability of X-ray-induced SWIR luminescence (X-IR) to monitor biodistribution and map lymphatic drainage. Our results indicate X-IR imaging is a promising new modality for preclinical applications and has potential for dual-modality molecular disease imaging.
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