X-ray-induced shortwave infrared biomedical imaging using rare-earth nanoprobes.
X-ray-induced shortwave infrared biomedical imaging using rare-earth nanoprobes.
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DOI:
10.1021/nl504123r
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发表时间:
2015-01-14
期刊:
影响因子:
10.8
通讯作者:
Xing L
中科院分区:
文献类型:
--
作者:
Naczynski DJ;Sun C;Türkcan S;Jenkins C;Koh AL;Ikeda D;Pratx G;Xing L
Shortwave infrared (SWIR or NIR-II) light provides significant advantages for imaging biological structures due to reduced autofluorescence and photon scattering. Here, we report on the development of rare-earth nanoprobes that exhibit SWIR luminescence following X-ray irradiation. We demonstrate the ability of X-ray-induced SWIR luminescence (X-IR) to monitor biodistribution and map lymphatic drainage. Our results indicate X-IR imaging is a promising new modality for preclinical applications and has potential for dual-modality molecular disease imaging.
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影响因子:
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