Measurement of photoreceptor layer in glaucoma: a spectral-domain optical coherence tomography study.
Measurement of photoreceptor layer in glaucoma: a spectral-domain optical coherence tomography study.
复制标题
DOI：
10.1155/2011/264803
复制
发表时间：
2011
影响因子：
1.9
通讯作者：
Leung CK
中科院分区：
文献类型：
--
作者：
Fan N;Huang N;Lam DS;Leung CK
Objective.使用谱域光学相干断层扫描（OCT）测量并比较正常眼和青光眼眼的感光层厚度。 方法. 38名健康志愿者和47名青光眼患者被纳入分析。随机选择每名参与者的一只眼睛，通过光谱域OCT（3D OCT-1000，Topcon，Tokyo，Japan）进行黄斑成像。由一名戴面具的观察者测量中心凹和视网膜旁（距中心凹1.5 mm）外核层（ONL）和内外段（IS+OS）层厚度。随机抽取30只正常眼，重复测量3次，测定重复性系数和组内相关系数。 结果感光细胞厚度的测量变异性低。ONL和IS+OS厚度的组内相关系数分别为0.96（95%置信区间：0.94-0.98）和0.82（95%置信区间：0.70-0.90）。虽然正常眼和青光眼组的黄斑旁ONL和IS+OS厚度没有差异（P ≤ .410），但青光眼组的黄斑中心凹ONL厚度大于正常眼（P = .011）。 结论.青光眼损害可能涉及感光层的结构变化。
Objective. To measure and compare photoreceptor layer thickness between normal and glaucomatous eyes using spectral-domain optical coherence tomography (OCT). Methods. Thirty-eight healthy normal volunteers and 47 glaucoma patients were included in the analysis. One eye from each participant was randomly selected for macula imaging by a spectral-domain OCT (3D OCT-1000, Topcon, Tokyo, Japan). The foveal and parafoveal (1.5 mm from the fovea) outer nuclear layer (ONL) and inner and outer segments (IS+OS) layer thicknesses were measured by a single masked observer. The measurements were repeated 3 times in a random sample of 30 normal eyes to determine the repeatability coefficient and intraclass correlation coefficient. Results. The measurement variabilities of photoreceptor thickness were low. The respective intraclass correlation coefficients of ONL and IS+OS thicknesses were 0.96 (95% confidence interval: 0.94–0.98) and 0.82 (95% confidence interval 0.70–0.90). While there were no differences in parafoveal ONL and IS+OS thicknesses between normal and glaucoma groups (P ≤ .410), the foveal ONL thickness was greater in glaucomatous eyes (P = .011) than in normal eyes. Conclusions. Glaucomatous damage may involve structural change in the photoreceptor layer.
登录
查看更多内容
影响因子：
4.4
作者：
Ishikawa, H;Stein, DM;Schuman, JS
通讯作者：
Schuman, JS
影响因子：
--
作者：
SIPPERLEY, JO;QUIGLEY, HA;GASS, JDM
通讯作者：
GASS, JDM
影响因子：
4.1
作者：
Velten, IM;Korth, M;Horn, FK
通讯作者：
Horn, FK
影响因子：
3.6
作者：
Nassif, N;Cense, B;de Boer, JF
通讯作者：
de Boer, JF
影响因子：
--
作者：
Weiner, A;Ripkin, DJ;Weidenthal, DT
通讯作者：
Weidenthal, DT