Echinochrome A Reverses Kidney Abnormality and Reduces Blood Pressure in a Rat Model of Preeclampsia.
Echinochrome A Reverses Kidney Abnormality and Reduces Blood Pressure in a Rat Model of Preeclampsia.
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棘红花 A 可逆转先兆子痫大鼠模型的肾脏异常并降低血压
DOI：
10.3390/md20110722
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发表时间：
2022-11-17
期刊：
影响因子：
5.4
通讯作者：
Zhang Y
中科院分区：
文献类型：
--
作者：
Cui H;Liu J;Vasileva EA;Mishchenko NP;Fedoreyev SA;Stonik VA;Zhang Y
本研究旨在观察棘色素A（Echinochrome A，EchA）对子痫前期大鼠模型全身变化的影响。结果显示，GD 8时通过渗透泵（1 μg/kg/min）输注血管紧张素II（Ang II）可增加收缩压和舒张压，降低胎儿体重和胎盘重量。肾小球直径扩大，毛细血管减少。Ang II组的心脏和肝脏没有观察到变化，但子宫上皮结构被破坏。GD 14时通过颈静脉给予EchA（100 μg/μL）可降低收缩压和舒张压并逆转肾小球改变，但胎儿或胎盘参数不受影响。Ech A仅部分逆转了对子宫的影响。Ang Ⅱ组子宫组织TNF-α mRNA表达增加，IL-10和VEGF mRNA表达减少，而EchA可恢复上述变化。在该组的肾脏、肝脏和心脏中观察到类似的趋势。此外，Bcl-2减少和Bcl-2/Bax比值显着降低，在肾脏和心脏的Ang II组，而EchA逆转这些变化。我们认为，EchA调节炎症和凋亡的关键系统器官在血管紧张素II诱导的大鼠先兆子痫，保留肾脏和子宫结构，降低血压。
We aimed to observe the effects of Echinochrome A (Ech A) on systemic changes using a rat model of preeclampsia. The results showed that an infusion of angiotensin II (Ang II) through an osmotic pump (1 μg/kg/min) on GD 8 increased systolic and diastolic blood pressures and reduced fetal weight and placental weight. The diameters of the glomeruli were expended and glomeruli capillaries were diminished. No change was observed in the heart and liver in the Ang II group, but epithelial structures were disrupted in the uterus. Ech A treatment on GD 14 (100 μg/μL) through the jugular vein reduced systolic and diastolic blood pressures and reversed glomerulus alterations, but the fetal or placental parameters were unaffected. Ech A only partly reversed the effect on the uterus. The mRNA expression of TNF–α was increased and IL–10 and VEGF were reduced in the uterus of the Ang II group, while Ech A restored these changes. A similar trend was observed in the kidney, liver, and heart of this group. Furthermore, Bcl–2 was reduced and Bcl–2/Bax ratios were significantly reduced in the kidney and heart of the Ang II group, while Ech A reversed these changes. We suggest that Ech A modulates inflammation and apoptosis in key systemic organs in Ang II-induced rat preeclampsia and preserves kidney and uterus structures and reduces blood pressure.
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影响因子：
5.4
作者：
Kim HK;Vasileva EA;Mishchenko NP;Fedoreyev SA;Han J
通讯作者：
Han J
DOI：
10.1161/hypertensionaha.113.01514
发表时间：
2013-12
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Cornelius DC;Hogg JP;Scott J;Wallace K;Herse F;Moseley J;Wallukat G;Dechend R;LaMarca B
通讯作者：
LaMarca B
影响因子：
5.9
作者：
Cho, KyoHee;Kang, Min Cheol;Kim, Sun Yeou
通讯作者：
Kim, Sun Yeou
影响因子：
8.3
作者：
Gadonski, Giovani;Babbette, B.;Granger, Joey P.
通讯作者：
Granger, Joey P.
DOI：
10.1016/j.jsgi.2005.02.005
发表时间：
2005-07-01
期刊：
JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION
影响因子：
--
作者：
Arriaga-Pizano, L;Jimenez-Zamudio, L;Hernandez-Guerrero, C
通讯作者：
Hernandez-Guerrero, C