Aging, Frailty, and the Microbiome-How Dysbiosis Influences Human Aging and Disease.
Aging, Frailty, and the Microbiome-How Dysbiosis Influences Human Aging and Disease.
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衰老，脆弱和微生物组的营养不良影响人类衰老和疾病。
DOI：
10.1053/j.gastro.2020.09.060
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发表时间：
2021-01
期刊：
影响因子：
29.4
通讯作者：
McCormick BA
中科院分区：
文献类型：
--
作者：
Haran JP;McCormick BA
人类肠道微生物组是细菌、原生动物、真菌和病毒的集合，它们共存于我们的身体中，对人类健康的保护、代谢和生理功能至关重要。肠道生态失调传统上与感染风险增加有关，但与不良炎症反应相关的肠道微生物群落结构失衡越来越多地被认为参与影响体内许多器官系统的疾病过程。此外，越来越明显的是，肠道生态失调和年龄相关疾病之间的联系可能在于肠道微生物组如何与肠粘膜和全身免疫系统进行通信，因为这些网络与脆弱性有着共同的相互联系。因此，我们讨论了我们对微生物组在衰老中发挥的重要作用的理解的最新进展，以及这些知识如何为潜在的新疗法打开大门，旨在塑造一个更少的微生态失调的微生物组，以预防或治疗与年龄相关的疾病。
The human gut microbiome is a collection of bacteria, protozoa, fungi, and viruses that coexist in our bodies and are essential in protective, metabolic, and physiologic functions of human health. Gut dysbiosis has traditionally been linked to increased risk of infection, but imbalances within the intestinal microbial community structure that correlate with untoward inflammatory responses are increasingly recognized as being involved in disease processes that affect many organ systems in the body. Furthermore, it is becoming more apparent that the connection between gut dysbiosis and age-related diseases may lie in how the gut microbiome communicates with both the intestinal mucosa and the systemic immune system, given that these networks have a common interconnection to frailty. We therefore discuss recent advances in our understanding of the important role the microbiome plays in aging and how this knowledge opens the door for potential novel therapeutics aimed at shaping a less dysbiotic microbiome to prevent or treat age-related diseases.
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影响因子：
3.7
作者：
Biagi E;Nylund L;Candela M;Ostan R;Bucci L;Pini E;Nikkïla J;Monti D;Satokari R;Franceschi C;Brigidi P;De Vos W
通讯作者：
De Vos W
DOI：
10.1038/nri3535
发表时间：
2013-11
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
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影响因子：
--
作者：
Biagi, Elena;Candela, Marco;Fairweather-Tait, Susan;Franceschi, Claudio;Brigidi, Patrizia
通讯作者：
Brigidi, Patrizia
影响因子：
7.3
作者：
Chen X;Hu Y;Cao Z;Liu Q;Cheng Y
通讯作者：
Cheng Y
影响因子：
4.8
作者：
Bian G;Gloor GB;Gong A;Jia C;Zhang W;Hu J;Zhang H;Zhang Y;Zhou Z;Zhang J;Burton JP;Reid G;Xiao Y;Zeng Q;Yang K;Li J
通讯作者：
Li J