Sudachi peel extract powder including the polymethoxylated flavone sudachitin improves visceral fat content in individuals at risk for developing diabetes.
Sudachi peel extract powder including the polymethoxylated flavone sudachitin improves visceral fat content in individuals at risk for developing diabetes.
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DOI：
10.1002/fsn3.2339
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发表时间：
2021-08
影响因子：
3.9
通讯作者：
Sakaue H
中科院分区：
文献类型：
--
作者：
Shikishima Y;Tsutsumi R;Kawakami A;Miura H;Nii Y;Sakaue H
体外和动物研究表明，日本柑橘的果皮提取物，包括sudachitin，改善高脂血症和减少肥胖。Sudachitin是一种多甲氧基化黄酮，据报道对脂质和葡萄糖代谢具有良好的作用，但临床试验的结果不一致。本研究的目的是通过一项随机对照试验，确定日本男性和女性食用sudachi果皮提取物粉末胶囊对内脏脂肪的影响。这是一项为期12周的随机、双盲、安慰剂对照试验，涉及41名年龄在30-65岁之间、BMI为23-30 kg/m2的受试者，随机分配接受相同外观的sudachi果皮提取物粉末（sudachitin 4.9 mg/天，n = 21）或安慰剂（n = 20）。主要结果指标是内脏脂肪量，在干预期间进行评估。41例受试者中有38例完成了方案。与安慰剂相比，苏达奇果皮提取物粉末显著降低了内脏脂肪与皮下脂肪的比例，并适度降低了腰围，腰围是代谢综合征的标志物。在这些受试者中，血糖控制和血脂没有显著变化。食用苏达奇果皮提取物粉末胶囊有利地改善了有患糖尿病风险的个体的内脏脂肪与皮下脂肪的比率，特别是在具有大内脏脂肪面积的个体中，同时不会对血糖控制产生不利影响。含有多甲氧基化黄酮sudachitin的柑橘（sudachi）果皮提取物已在体外和动物模型中显示出前景。与安慰剂相比，sudachi果皮提取物显著降低了内脏脂肪与皮下脂肪的比例（-0.0265%，p = .0485），并适度降低了内脏脂肪和腰围。
In vitro and animal studies have indicated that extracts from the peel of the Japanese Citrus sudachi, including sudachitin, ameliorate hyperlipidemia and reduce obesity. Sudachitin, a polymethoxylated flavone, has been reported as having favorable effects on lipid and glucose metabolism but results from clinical trials have been inconsistent. The aim of this study was to determine the effect of consuming capsules of sudachi peel extract powder on visceral fat in Japanese men and women in a randomized controlled trial. This was a 12‐week randomized, double‐blind, placebo‐controlled trial involving 41 participants aged 30–65 years with BMI 23–30 kg/m2, randomly allocated to receive either sudachi peel extract powder (sudachitin 4.9 mg/day, n = 21) or placebo (n = 20) of identical appearance. The primary outcome measure was visceral fat mass, assessed during intervention. Thirty‐eight of the 41 subjects completed the protocol. Compared with placebo, sudachi peel extract powder significantly reduced the ratio of visceral fat to subcutaneous fat, and moderately reduced waist circumference, a metabolic syndrome marker. Glycemic control and lipid profile were not changed significantly in these subjects. Consumption of capsules of sudachi peel extract powder favorably improves the ratio of visceral fat to subcutaneous fat in individuals at risk for developing diabetes, especially in individuals with large visceral fat area, while not adversely affecting glycemic control. Extracts of Citrus sudachi (sudachi) peel, containing the polymethoxylated flavone sudachitin, have shown promise in vitro and in animal models. Compared with placebo, sudachi peel extract significantly reduced the ratio of visceral fat to subcutaneous fat (−0.0265%, p = .0485), and moderately reduced visceral fat and waist circumference.
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