Biology of ageing and role of dietary antioxidants.
Biology of ageing and role of dietary antioxidants.
复制标题
DOI：
10.1155/2014/831841
复制
发表时间：
2014
影响因子：
--
通讯作者：
Chen ZY
中科院分区：
文献类型：
--
作者：
Peng C;Wang X;Chen J;Jiao R;Wang L;Li YM;Zuo Y;Liu Y;Lei L;Ma KY;Huang Y;Chen ZY
人们对饮食和衰老之间关系的兴趣越来越大。研究表明，饮食热量限制和一些抗氧化剂可以延长各种衰老模型的寿命。一方面，氧对于需氧生物是必不可少的，因为它是线粒体中的最终电子受体。另一方面，氧气是有害的，因为它可以不断产生活性氧（ROS），这被认为是导致生物体老化的因素。为了清除细胞中的这些ROS，需氧生物具有抗氧化防御系统，该系统由一系列酶组成，即超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GPx）和谷胱甘肽还原酶（GR）。此外，膳食抗氧化剂，包括抗坏血酸，维生素A，维生素C，α-生育酚和植物类黄酮也能够抑制细胞中的ROS，因此理论上可以延长生物体的寿命。在这方面，包括儿茶素、茶黄素、苹果多酚、黑米花青素和蓝莓多酚在内的各种抗氧化剂已被证明能够延长果蝇的寿命。本文以果蝇为研究对象，综述了现代衰老生物学理论、膳食抗氧化剂在衰老中的作用以及抗氧化剂延长寿命的机制。
Interest in relationship between diet and ageing is growing. Research has shown that dietary calorie restriction and some antioxidants extend lifespan in various ageing models. On the one hand, oxygen is essential to aerobic organisms because it is a final electron acceptor in mitochondria. On the other hand, oxygen is harmful because it can continuously generate reactive oxygen species (ROS), which are believed to be the factors causing ageing of an organism. To remove these ROS in cells, aerobic organisms possess an antioxidant defense system which consists of a series of enzymes, namely, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR). In addition, dietary antioxidants including ascorbic acid, vitamin A, vitamin C, α-tocopherol, and plant flavonoids are also able to scavenge ROS in cells and therefore theoretically can extend the lifespan of organisms. In this connection, various antioxidants including tea catechins, theaflavins, apple polyphenols, black rice anthocyanins, and blueberry polyphenols have been shown to be capable of extending the lifespan of fruit flies. The purpose of this review is to brief the literature on modern biological theories of ageing and role of dietary antioxidants in ageing as well as underlying mechanisms by which antioxidants can prolong the lifespan with focus on fruit flies as an model.
登录
查看更多内容
DOI：
10.1073/pnas.0403493101
发表时间：
2004-08-31
影响因子：
11.1
作者：
Bauer, JH;Goupil, S;Helfand, SL
通讯作者：
Helfand, SL
影响因子：
158.5
作者：
ANDERSON, JW;JOHNSTONE, BM;COOKNEWELL, ME
通讯作者：
COOKNEWELL, ME
影响因子：
5.4
作者：
Arts, ICW;Jacobs, DR;Folsom, AR
通讯作者：
Folsom, AR
影响因子：
7.4
作者：
Boyd, Olga;Weng, Peter;Zou, Sige
通讯作者：
Zou, Sige
影响因子：
10.3
作者：
Feskanich, D;Ziegler, RG;Colditz, GA
通讯作者：
Colditz, GA