Intercellular communications in multispecies oral microbial communities.
Intercellular communications in multispecies oral microbial communities.
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DOI：
10.3389/fmicb.2014.00328
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发表时间：
2014
影响因子：
5.2
通讯作者：
Shi W
中科院分区：
文献类型：
--
作者：
Guo L;He X;Shi W
口腔中含有700多种微生物，它们参与了广泛的细胞-细胞相互作用。这些相互作用有助于形成高度结构化的多物种群落，使它们能够发挥生理功能，并诱导协同发病机制。口腔微生物物种之间的共同粘附影响着它们在口腔中的定植，并在很大程度上影响着高度组织化的多微生物群落结构的时空形成。个体物种还通过代谢相互作用与其他邻近物种竞争和合作，这不仅改变了当地的微环境，如pH和氧气量，使其更适合其他物种的生长，而且还通过最大限度地从有限的底物中提取能量，为参与微生物提供了一个代谢框架。在微生物群落中，细菌与邻近共生菌的直接物理接触可以启动信号级联，并根据所接触的不同物种实现基因表达调控。除了通过细胞间接触进行沟通外，由能力刺激肽（CSPs）和自诱导2 （AI-2）等小信号分子介导的群体感应（quorum sensing， QS）在细菌生理和生态中起着重要作用。本文将总结口腔微生物通过细胞接触依赖的物理相互作用、代谢相互依赖以及协调的信号系统参与细胞间通讯的证据，以建立和维持平衡的微生物群落。
The oral cavity contains more than 700 microbial species that are engaged in extensive cell–cell interactions. These interactions contribute to the formation of highly structured multispecies communities, allow them to perform physiological functions, and induce synergistic pathogenesis. Co-adhesion between oral microbial species influences their colonization of oral cavity and effectuates, to a large extent, the temporal and spatial formation of highly organized polymicrobial community architecture. Individual species also compete and collaborate with other neighboring species through metabolic interactions, which not only modify the local microenvironment such as pH and the amount of oxygen, making it more suitable for the growth of other species, but also provide a metabolic framework for the participating microorganisms by maximizing their potential to extract energy from limited substrates. Direct physical contact of bacterial species with its neighboring co-habitants within microbial community could initiate signaling cascade and achieve modulation of gene expression in accordance with different species it is in contact with. In addition to communication through cell–cell contact, quorum sensing (QS) mediated by small signaling molecules such as competence-stimulating peptides (CSPs) and autoinducer-2 (AI-2), plays essential roles in bacterial physiology and ecology. This review will summarize the evidence that oral microbes participate in intercellular communications with co-inhabitants through cell contact-dependent physical interactions, metabolic interdependencies, as well as coordinative signaling systems to establish and maintain balanced microbial communities.
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影响因子：
3.2
作者：
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通讯作者：
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