mPFC catecholamines modulate attentional capture by appetitive distracters and attention to time in a peak-interval procedure in rats.
mPFC catecholamines modulate attentional capture by appetitive distracters and attention to time in a peak-interval procedure in rats.
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DOI：
10.1037/bne0000528
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发表时间：
2022-10
影响因子：
1.9
通讯作者：
Buhusi, Mona
中科院分区：
文献类型：
--
作者：
Buhusi, Catalin, V;Matthews, Alexander R.;Buhusi, Mona
目前尚不清楚干扰者延迟间隔计时行为的行为和神经机制。干扰物在相当大的动态范围内延迟计时：一些干扰物对计时没有影响（“运行”），而另一些则似乎“停止”计时；一些干扰物会在其偏移时重新启动（“重置”）整个计时机制，而其他干扰物似乎在其终止后很久才捕获注意力资源（“过度重置”）。虽然运行重置延迟范围是由分时假说解释的，但“过度重置”的行为和神经机制目前尚不确定。我们研究了新颖性（新奇/熟悉）和重要性（重要/无关紧要）在分散注意力的时间延迟效应中的作用，以及在大鼠峰值间隔过程中局部输注 NDRI 诺米芬辛对内侧前额叶皮层 (mPFC) 儿茶酚胺的作用。结果表明，各组之间的时间延迟存在差异，这表明新颖性和重要性都发挥了作用：无关紧要的、熟悉的干扰物“停止”时间，新颖的干扰物“重置”时间，而食欲调节的干扰物“过度重置”时间。 mPFC 输注诺米芬辛以“U”形方式调节食欲性干扰物的注意力捕获，减少了新的干扰物后的延迟，但在无关紧要的、熟悉的干扰物后没有效果。这些结果并不是由于诺米芬辛影响计时准确性、精确度或峰值响应率。结果可能有助于阐明间隔时间和对时间的注意力背后的行为和生理机制，并可能有助于开发新的注意力障碍治疗策略。
The behavioral and neural mechanisms by which distracters delay interval timing behavior are currently unclear. Distracters delay timing in a considerable dynamic range: Some distracters have no effect on timing ( “run”), while others seem to “stop” timing; some distracters re-start (“reset”) the entire timing mechanisms at their offset, while others seem to capture attentional resources long after their termination (“over-reset”). While the run-reset range of delays is accounted for by the Time-Sharing Hypothesis, the behavioral and neural mechanisms of “over-resetting” are currently uncertain. We investigated the role of novelty (novel / familiar) and significance (consequential / inconsequential) in the time-delaying effect of distracters, and the role of medial prefrontal cortex (mPFC) catecholamines by local infusion of NDRI nomifensine, in a peak-interval procedure in rats. Results indicate differences in time-delay between groups suggesting a role for both novelty and significance: Inconsequential, familiar distracters “stopped” timing, novel distracters “reset” timing, while appetitively-conditioned distracters “over-reset” timing. mPFC infusion of nomifensine modulated attentional capture by appetitive distracters in a “U”-shaped fashion, reduced the delay after novel distracters, but had no effects after inconsequential, familiar distracters. These results were not due to nomifensine affecting either timing accuracy, precision, or peak response rate. Results may help elucidate the behavioral and physiological mechanisms underlying interval timing and attention to time, and may contribute to developing new treatment strategies for disorders of attention.
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影响因子：
--
作者：
Matthews AR;Buhusi M;Buhusi CV
通讯作者：
Buhusi CV
影响因子：
3.3
作者：
CARBONI, E;IMPERATO, A;DICHIARA, G
通讯作者：
DICHIARA, G
影响因子：
1.3
作者：
Buhusi, Catalin V.;Matthews, Alexander R.
通讯作者：
Matthews, Alexander R.
影响因子：
2.7
作者：
Buhusi M;Bartlett MJ;Buhusi CV
通讯作者：
Buhusi CV
影响因子：
3.3
作者：
Buhusi M;Olsen K;Buhusi CV
通讯作者：
Buhusi CV