Evolutionary implications of a third lymphocyte lineage in lampreys.
Evolutionary implications of a third lymphocyte lineage in lampreys.
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作者：
有颌脊椎动物（有颌动物）和无颌脊椎动物（圆口动物）具有不同的适应性免疫系统。颚口类使用属于免疫球蛋白超家族的T细胞和B细胞抗原受体。圆口动物、七鳃鳗和八目鳗则使用富含亮氨酸的重复蛋白来构建可变淋巴细胞受体（VLRs），其中两种类型的VLRA和VLRB由类似颌口T和B细胞的淋巴细胞表达。在这里，我们定义了另一个谱系的T细胞样淋巴细胞，表达最近发现的VLRC受体。VLRC+和VLRA+淋巴细胞都表达颌口γδ和αβ T细胞用于其分化的基因的直系同源物，在“胸腺样”鳃区进行VLRC和VLRA组装和库多样化，并仅表达其VLRs作为细胞表面蛋白。我们的研究结果表明，两个原始T细胞谱系和一个原型B细胞谱系的遗传程序已经存在于大约5亿年前的最后一个共同脊椎动物祖先中。我们认为，不同的T细胞样谱系的功能特化是原始免疫系统的一个古老特征。
Jawed vertebrates (gnathostomes) and jawless vertebrates (cyclostomes) have different adaptive immune systems. Gnathostomes use T- and B-cell antigen receptors belonging to the immunoglobulin superfamily. Cyclostomes, the lampreys and hagfish, instead use leucine-rich repeat proteins to construct variable lymphocyte receptors (VLRs), two types of which, VLRA and VLRB, are reciprocally expressed by lymphocytes resembling gnathostome T and B cells. Here we define another lineage of T-cell-like lymphocytes that express the recently identified VLRC receptors. Both VLRC+ and VLRA+ lymphocytes express orthologues of genes that gnathostome γδ and αβ T cells use for their differentiation, undergo VLRC and VLRA assembly and repertoire diversification in the ‘thymoid’ gill region, and express their VLRs solely as cell-surface proteins. Our findings suggest that the genetic programmes for two primordial T-cell lineages and a prototypic B-cell lineage were already present in the last common vertebrate ancestor approximately 500 million years ago. We propose that functional specialization of distinct T-cell-like lineages was an ancient feature of a primordial immune system.
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影响因子：
56.9
作者：
Melichar, Heather J.;Narayan, Kavitha;Kang, Joonsoo
通讯作者：
Kang, Joonsoo
影响因子：
30.8
作者：
Smith, Jeramiah J.;Kuraku, Shigehiro;Holt, Carson;Sauka-Spengler, Tatjana;Jiang, Ning;Campbell, Michael S.;Yandell, Mark D.;Manousaki, Tereza;Meyer, Axel;Bloom, Ona E.;Morgan, Jennifer R.;Buxbaum, Joseph D.;Sachidanandam, Ravi;Sims, Carrie;Garruss, Alexander S.;Cook, Malcolm;Krumlauf, Robb;Wiedemann, Leanne M.;Sower, Stacia A.;Decatur, Wayne A.;Hall, Jeffrey A.;Amemiya, Chris T.;Saha, Nil R.;Buckley, Katherine M.;Rast, Jonathan P.;Das, Sabyasachi;Hirano, Masayuki;McCurley, Nathanael;Guo, Peng;Rohner, Nicolas;Tabin, Clifford J.;Piccinelli, Paul;Elgar, Greg;Ruffier, Magali;Aken, Bronwen L.;Searle, Stephen M. J.;Muffato, Matthieu;Pignatelli, Miguel;Herrero, Javier;Jones, Matthew;Brown, C. Titus;Chung-Davidson, Yu-Wen;Nanlohy, Kaben G.;Libants, Scot V.;Yeh, Chu-Yin;McCauley, David W.;Langeland, James A.;Pancer, Zeev;Fritzsch, Bernd;de Jong, Pieter J.;Zhu, Baoli;Fulton, Lucinda L.;Theising, Brenda;Flicek, Paul;Bronner, Marianne E.;Warren, Wesley C.;Clifton, Sandra W.;Wilson, Richard K.;Li, Weiming
通讯作者：
Li, Weiming
影响因子：
29.7
作者：
Boehm T;McCurley N;Sutoh Y;Schorpp M;Kasahara M;Cooper MD
通讯作者：
Cooper MD
影响因子：
64.8
作者：
Guo, Peng;Hirano, Masayuki;Herrin, Brantley R.;Li, Jianxu;Yu, Cuiling;Sadlonova, Andrea;Cooper, Max D.
通讯作者：
Cooper, Max D.
DOI：
10.1038/nrg2703
发表时间：
2010-01
期刊：
Nature reviews. Genetics
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作者：
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