Longitudinal measurements of MRI-T2 in boys with Duchenne muscular dystrophy: effects of age and disease progression.
Longitudinal measurements of MRI-T2 in boys with Duchenne muscular dystrophy: effects of age and disease progression.
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DOI：
10.1016/j.nmd.2013.12.012
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发表时间：
2014-05
影响因子：
2.8
通讯作者：
Vandenborne, K.
中科院分区：
文献类型：
--
作者：
Willcocks, R. J.;Arpan, I. A.;Forbes, S. C.;Lott, D. J.;Senesac, C. R.;Senesac, E.;Deol, J.;Triplett, W. T.;Baligand, C.;Daniels, M. J.;Sweeney, H. L.;Walter, G. A.;Vandenborne, K.
Duchenne muscular dystrophy (DMD) is characterized by in increased muscle damage and progressive replacement of muscle by noncontractile tissue. Both of these pathological changes can lengthen the MRI transverse proton relaxation time (T2). The current study measured longitudinal changes in T2 and its distribution in the lower leg of 16 boys with DMD (5–13 years, 15 ambulatory), 15 healthy controls (5–13 years). These muscles were chosen to allow extended longitudinal monitoring, due to their slow progression compared with proximal muscles in DMD. In the soleus muscle of boys with DMD, T2 and the percentage of pixels with an elevated T2 (≥2 SD above control mean T2) increased significantly over one year and two years, while the width of the T2 histogram increased over two years. Changes in soleus T2 variables were significantly greater in 9–13 year old compared with 5–8 year old boys with DMD. Significant correlations between the change in all soleus T2 variables over two years and the change in functional measures over two years were found. MRI measurement of muscle T2 in boys with DMD is sensitive to disease progression and shows promise as a clinical outcome measure.
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影响因子：
2.9
作者：
Arpan, Ishu;Forbes, Sean C.;Lott, Donovan J.;Senesac, Claudia R.;Daniels, Michael J.;Triplett, William T.;Deol, Jasjit K.;Sweeney, H. Lee;Walter, Glenn A.;Vandenborne, Krista
通讯作者：
Vandenborne, Krista
DOI：
10.1002/jmri.1880040113
发表时间：
1994-01-01
期刊：
JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING
影响因子：
--
作者：
HUANG, YM;MAJUMDAR, S;MILLER, RG
通讯作者：
MILLER, RG
影响因子：
3.3
作者：
Gambarota, G;Cairns, BE;Mulkern, RV
通讯作者：
Mulkern, RV
影响因子：
5
作者：
Wren, Tishya A. L.;Bluml, Stefan;Gilsanz, Vicente
通讯作者：
Gilsanz, Vicente
影响因子：
3.5
作者：
Porter, JD;Khanna, S;Andrade, FH
通讯作者：
Andrade, FH