Associations between imprinted gene differentially methylated regions, appetitive traits and body mass index in children.
Associations between imprinted gene differentially methylated regions, appetitive traits and body mass index in children.
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DOI：
10.1111/ijpo.12454
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发表时间：
2019-03
影响因子：
3.8
通讯作者：
Fuemmeler BF
中科院分区：
文献类型：
--
作者：
Do EK;Zucker NL;Huang ZY;Schechter JC;Kollins SH;Maguire RL;Murphy SK;Hoyo C;Fuemmeler BF
关于饮食行为的遗传影响的知识正在扩大;然而，关于表观遗传变异对儿童食欲特征和体重指数（BMI）的贡献却知之甚少。本研究的目的是探索印迹基因（胰岛素样生长因子2/H19和Delta样，果蝇，同源1/母系表达基因3）的差异甲基化区域（DMR）甲基化之间的关系，使用从脐带血白细胞提取的DNA，两个受遗传影响的食欲性状（食物反应性和饱腹感反应性）和BMI。数据来自新生儿表观遗传学研究的参与者（N = 317;平均年龄= 3.6岁; SD = 1.8岁）。实施条件过程模型来调查印记基因的DMR和BMI之间的关联，并测试这种关联是否由食欲性状和出生体重介导，并由性别调节。食欲性状和出生体重没有介导DMR甲基化之间的关系。胰岛素样生长因子2 DMR甲基化的增加与更高的饱腹感反应相关。较高的饱腹感反应与较低的BMI相关。DMR甲基化、食欲性状和BMI之间的关联因性别而异。这是证明出生前建立的表观遗传变异与儿童食欲性状和BMI之间关联的首批研究之一，为揭示某些个体肥胖易感食欲性状的遗传和表观遗传机制提供了支持。
Knowledge regarding genetic influences on eating behaviours is expanding; yet less is known regarding contributions of epigenetic variation to appetitive traits and body mass index (BMI) in children. The purpose of this study was to explore relationships between methylation at differentially methylated regions (DMRs) of imprinted genes (insulin-like growth factor 2/H19 and Delta-like, Drosophila, homolog 1/maternally expressed gene 3) using DNA extracted from umbilical cord blood leucocytes, two genetically influenced appetitive traits (food responsiveness and satiety responsiveness) and BMI. Data were obtained from participants (N = 317; mean age = 3.6 years; SD = 1.8 years) from the Newborn Epigenetic STudy. Conditional process models were implemented to investigate the associations between DMRs of imprinted genes and BMI, and test whether this association was mediated by appetitive traits and birthweight and moderated by sex. Appetitive traits and birthweight did not mediate the relationship between methylation at DMRs. Increased insulin-like growth factor 2 DMR methylation was associated with higher satiety responsiveness. Higher satiety responsiveness was associated with lower BMI. Associations between methylation at DMRs, appetitive traits and BMI differed by sex. This is one of the first studies to demonstrate associations between epigenetic variation established prior to birth with appetitive traits and BMI in children, providing support for the need to uncover genetic and epigenetic mechanisms for appetitive traits predisposing some individuals to obesity.
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影响因子：
7.1
作者：
Llewellyn, Clare H.;van Jaarsveld, Cornelia H. M.;Wardle, Jane
通讯作者：
Wardle, Jane
DOI：
10.1186/1479-5868-5-49
发表时间：
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影响因子：
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影响因子：
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作者：
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通讯作者：
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