Racial differences in the systemic inflammatory response to prostate cancer.
Racial differences in the systemic inflammatory response to prostate cancer.
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DOI：
10.1371/journal.pone.0252951
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Rybicki BA
中科院分区：
文献类型：
--
作者：
Rundle AG;Sadasivan SM;Chitale DA;Gupta NS;Williamson SR;Kryvenko ON;Chen Y;Bobbitt K;Tang D;Rybicki BA
全身炎症可能会增加前列腺癌进展的风险，但它在前列腺癌易感性中所起的作用尚不清楚。从10,000多名接受了前列腺活检或经尿道电切术并发现良性病变的男性队列中，我们分析了在1至18年的随访期内发现的517例前列腺癌病例和373例接受一次或多次白细胞检测的对照组。多水平、多变量纵向模型适用于两种全身炎症指标，即中性粒细胞/淋巴细胞比率(NLR)和单核细胞/淋巴细胞比率(MLR)，以确定与前列腺癌风险增加相关的NLR和MLR轨迹。对于这两种方法，我们没有发现病例/对照状态在轨迹上的显著差异，然而，在NLR轨迹建模中，种族(白人或黑人)和病例对照状态之间存在显著的交互作用。在种族特定的模型中，随着时间的推移，白人对照组的NLR和MLR值一直高于白人病例，而在黑人男性中，NLR和MLR轨迹的病例对照差异并不明显。当病例被归类为攻击性病例与非攻击性病例时，白人男性之间随时间的NLR和MLR值在病例对照中的差异在非攻击性病例中最为明显。对于白人男性中的NLR，在整个观察期间，在最初的前列腺标本中有炎症的男性，观察到了显著的病例对照差异。在白人男性中，在最初的阴性活检后监测NLR和MLR轨迹可能有助于监测前列腺癌的风险。
Systemic inflammation may increase risk for prostate cancer progression, but the role it plays in prostate cancer susceptibility is unknown. From a cohort of over 10,000 men who had either a prostate biopsy or transurethral resection that yielded a benign finding, we analyzed 517 incident prostate cancer cases identified during follow-up and 373 controls with one or more white blood cell tests during a follow-up period between one and 18 years. Multilevel, multivariable longitudinal models were fit to two measures of systemic inflammation, neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR), to determine NLR and MLR trajectories associated with increased risk for prostate cancer. For both measures, we found no significant differences in the trajectories by case/control status, however in modeling NLR trajectories there was a significant interaction between race (white or Black and case-control status. In race specific models, NLR and MLR values were consistently higher over time among white controls than white cases while case-control differences in NLR and MLR trajectories were not apparent among Black men. When cases were classified as aggressive as compared to non-aggressive, the case-control differences in NLR and MLR values over time among white men were most apparent for non-aggressive cases. For NLR among white men, significant case-control differences were observed for the entire duration of observation for men who had inflammation in their initial prostate specimen. It is possible that, among white men, monitoring of NLR and MLR trajectories after an initial negative biopsy may be useful in monitoring prostate cancer risk.
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