Association of polymorphisms in heat shock protein 70 genes with the susceptibility to noise-induced hearing loss: A meta-analysis.
Association of polymorphisms in heat shock protein 70 genes with the susceptibility to noise-induced hearing loss: A meta-analysis.
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热休克蛋白 70 基因多态性与噪声性听力损失易感性的关联荟萃分析。
DOI：
10.1371/journal.pone.0188195
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Xiao H
中科院分区：
文献类型：
--
作者：
Zong S;Zeng X;Liu T;Wan F;Luo P;Xiao H
多项病例对照研究报道了热休克蛋白70基因单核苷酸多态性（SNPs）与噪声性听力损失（NIHL）的关系。然而，他们的结论相互矛盾。本荟萃分析旨在确定HSP 70变异与NIHL易感性的关系。在PubMed、Web of Science、EMBASE和万方中文数据库中进行系统的文献检索。根据异质性检验中的I2值，在固定或随机效应模型中计算合并比值比（OR）、95%置信区间（CI）和p值。纳入了4篇文章，包含5项研究，包括633例病例和926例对照。在等位基因、纯合子和显性模型下，rs 1061581的合并OR（95%CI，p值）分别为1.32（1.06-1.67，p = 0.019）、1.93（1.10-3.36，p = 0.021）和1.455（1.408-2.019，p = 0.025）。此外，在所有五种遗传模型下，高加索人的rs 2227956与NIHL易感性之间存在显著关联。我们没有发现足够的证据证明其他三个SNPs（rs 1043618，rs 2763979和rs 2075800）与NIHL易感性之间的关联。这项荟萃分析表明，两个HSP 70变异，rs 1061581和rs 2227956，可能是NIHL的遗传易感因素。需要更大规模的研究来进一步更新结果。
Several case-control studies reported the relationship between single nucleotide polymorphisms (SNPs) in HSP70 genes and noise-induced hearing loss (NIHL). However, their conclusions are conflicting. This meta-analysis aims to identify the association of HSP70 variants and NIHL susceptibility. A systematical literature search was performed in PubMed, Web of Science, EMBASE, and Wanfang Chinese database. The pooled odds radio (OR), 95% confidence interval (CI) and p value were calculated in fixed- or random-effects model according to the I2 value in the heterogeneity test. Four articles containing five studies, including 633 cases and 926 controls, were included. Under the allele, homozygote and dominant model, the pooled ORs (95%CI, p-value) of rs1061581 were 1.32 (1.06–1.67, p = 0.019), 1.93 (1.10–3.36, p = 0.021) and 1.455 (1.408–2.019, p = 0.025), respectively. In addition, a significant association was found between rs2227956 in Caucasians and the NIHL susceptibility under all five genetic models. We did not discover evidence sufficient to prove the associations between the other three SNPs (rs1043618, rs2763979 and rs2075800) and the NIHL susceptibility. This meta-analysis indicated that the two HSP70 variants, rs1061581 and rs2227956, may serve as genetic susceptibility factors for NIHL. Larger scale studies are required to further update the results.
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HOGG1中的功能性SER326CYS多态性与中国人群的噪声引起的听力损失有关。
影响因子：
3.7
作者：
Shen H;Cao J;Hong Z;Liu K;Shi J;Ding L;Zhang H;Du C;Li Q;Zhang Z;Zhu B
通讯作者：
Zhu B
影响因子：
3.5
作者：
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通讯作者：
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影响因子：
2.8
作者：
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通讯作者：
Van Camp, G
影响因子：
2.8
作者：
Lin, Cheng-Yu;Wu, Jiunn-Liang;Guo, Yueliang Leon
通讯作者：
Guo, Yueliang Leon
影响因子：
1.7
作者：
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通讯作者：
Ghayour-Mobarhan, Majid