Sex and exercise interact to alter the expression of anabolic androgenic steroid-induced anxiety-like behaviors in the mouse.
Sex and exercise interact to alter the expression of anabolic androgenic steroid-induced anxiety-like behaviors in the mouse.
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DOI：
10.1016/j.yhbeh.2014.04.008
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发表时间：
2014-07
影响因子：
3.5
通讯作者：
Henderson, Leslie P.
中科院分区：
文献类型：
--
作者：
Onakomaiya, Marie M.;Porter, Donna M.;Oberlander, Joseph G.;Henderson, Leslie P.
关键词：
合成代谢雄激素类固醇（AAS）被两性服用，以提高运动表现和身体形象，几乎总是与锻炼计划相结合。虽然服用AAS可以改善身体素质，但长期使用AAS会促进负面行为，包括焦虑。很少有研究直接比较AAS对男性和女性的影响，或评估运动和AAS的相互作用。我们发现，AAS增加了雌性小鼠而不是雄性小鼠的焦虑样行为，而自愿运动加剧了这些性别特异性差异。我们还表明，促焦虑肽促肾上腺皮质激素释放因子（CRF）的水平在男性中明显更高，但AAS选择性地增加了女性的CRF水平，从而消除了这种性别特异性差异。运动没有改善aas引起的焦虑或改变女性的CRF水平。运动对男性有抗焦虑作用，但这种行为结果与CRF水平无关。脑源性神经营养因子（BDNF）也与焦虑的表达有关。与CRF一样，男性海马BDNF mRNA水平明显高于女性。AAS和运动对雌性BDNF mRNA无影响。在男性中，运动的抗焦虑作用与BDNF mRNA的增加相关，而aas诱导的BDNF mRNA的变化与焦虑无关。总之，我们发现AAS会引起焦虑的性别差异，而自愿运动则会加剧这些差异。此外，我们的数据表明，这些行为结果可能反映了AAS和运动对扩展杏仁核内性别分化的CRF信号系统的趋同作用。
Anabolic androgenic steroids (AAS) are taken by both sexes to enhance athletic performance and body image, nearly always in conjunction with an exercise regime. Although taken to improve physical attributes, chronic AAS use can promote negative behavior, including anxiety. Few studies have directly compared the impact of AAS use in males versus females or assessed the interaction of exercise and AAS. We show that AAS increase anxiety-like behaviors in female but not male mice and that voluntary exercise accentuates these sex-specific differences. We also show that levels of the anxiogenic peptide corticotrophin releasing factor (CRF) are significantly greater in males, but that AAS selectively increase CRF levels in females, thus abrogating this sex-specific difference. Exercise did not ameliorate AAS-induced anxiety or alter CRF levels in females. Exercise was anxiolytic in males, but this behavioral outcome did not correlate with CRF levels. Brain-derived neurotrophic factor (BDNF) has also been implicated in the expression of anxiety. As with CRF, levels of hippocampal BDNF mRNA were significantly greater in males than females. AAS and exercise were without effect on BDNF mRNA in females. In males, anxiolytic effects of exercise correlated with increased BDNF mRNA, however AAS-induced changes in BDNF mRNA and anxiety did not. In sum, we find that AAS elicit sex-specific differences in anxiety and that voluntary exercise accentuates these differences. In addition, our data suggest that these behavioral outcomes may reflect convergent actions of AAS and exercise on a sexually differentiated CRF signaling system within the extended amygdala.
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影响因子：
3.5
作者：
Blasberg, ME;Clark, AS
通讯作者：
Clark, AS
影响因子：
4.2
作者：
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影响因子：
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作者：
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DOI：
10.1016/s1056-4993(18)30214-1
发表时间：
1998-10-01
影响因子：
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作者：
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通讯作者：
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影响因子：
2.9
作者：
Burghardt, PR;Fulk, LJ;Wilson, MA
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