The major locus for mouse adenovirus susceptibility maps to genes of the hematopoietic cell surface-expressed LY6 family.
The major locus for mouse adenovirus susceptibility maps to genes of the hematopoietic cell surface-expressed LY6 family.
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DOI：
10.4049/jimmunol.0903363
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发表时间：
2010-03-15
期刊：
影响因子：
--
通讯作者：
Chesler EJ
中科院分区：
文献类型：
--
作者：
Spindler KR;Welton AR;Lim ES;Duvvuru S;Althaus IW;Imperiale JE;Daoud AI;Chesler EJ
对小鼠腺病毒1型（MAV-1）的易感性与主要数量性状位点（QTL）Msq 1相关。Msq 1最初定位于SJL/J和BALB/cJ近交系小鼠杂交的小鼠染色体（Chr）15的13 Mb区域。我们现在已经缩小Msq 1到0.75 Mb的区间从74.68到75.43 Mb定义的两个匿名标记，rs 8259436和D15 Spn 14，使用数据从1396回交小鼠。关键区间包括14个Ly 6或Ly 6相关基因，包括Ly 6a（编码Sca-1/TAP）、Ly 6 e（Sca-2/Tsa 1）、Ly 6 g（Gr-1）和gpihbp 1（GPI锚定HDL结合蛋白1），以及编码醛固酮合酶（Cyp 11b 2）的基因。Ly 6家族成员是病毒易感基因的有吸引力的候选者，因为它们的产物是在淋巴样和髓样细胞上表达的GPI锚定的膜蛋白，具有细胞粘附和细胞信号传导的功能。为了确定品系间的易感性变化，并产生额外的资源克隆Msq 1，我们分析了以前未经测试的近交系小鼠品系的易感性表型。随后，在271只（129 S6/SvEvTac x BALB/cJ）F1 x BALB/cJ回交小鼠群体中，使用Chr 15上的多态性遗传标记将菌株129 S6/SvEvTac的易感性定位于Ly 6复合物区域。我们确定了一个主要的129 S6/SvEvTac易感等位基因，Msq 1129 S6，在同一地区的Msq 1 SJL的Chr 15。结果表明，MAV-1易感性的主要宿主因素可能是Ly 6基因家族的成员。
Susceptibility to mouse adenovirus type 1 (MAV-1) is associated with the major quantitative trait locus (QTL) Msq1. Msq1 was originally mapped to a 13 megabase (Mb) region of mouse Chromosome (Chr) 15 in crosses between SJL/J and BALB/cJ inbred mice. We have now narrowed Msq1 to a 0.75 Mb interval from 74.68 to 75.43 Mb defined by two anonymous markers, rs8259436 and D15Spn14, using data from 1396 backcross mice. The critical interval includes fourteen Ly6 or Ly6-related genes including Ly6a (encoding Sca-1/TAP), Ly6e (Sca-2/Tsa1), Ly6g (Gr-1) and gpihbp1 (GPI-anchored HDL-binding protein 1), as well as the gene encoding an aldosterone synthase (Cyp11b2). The Ly6 family members are attractive candidates for virus susceptibility genes because their products are GPI-anchored membrane proteins expressed on lymphoid and myeloid cells, with proposed functions in cell adhesion and cell signaling. To determine interstrain variation in susceptibility and produce additional resources for cloning Msq1, we assayed the susceptibility phenotype of four previously untested inbred mouse strains. Susceptibility of strain 129S6/SvEvTac was subsequently localized to the Ly6 complex region using polymorphic genetic markers on Chr 15 in a population of 271 (129S6/SvEvTac x BALB/cJ)F1 x BALB/cJ backcross mice. We identified a major 129S6/SvEvTac susceptibility allele, Msq1129S6, on Chr 15 in the same region as Msq1SJL. The results indicate that a major host factor in MAV-1 susceptibility is likely to be a member of the Ly6 gene family.
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LY6C+“炎症单核细胞”是在西尼罗河病毒脑炎中以致病方式募集的小胶质前体。
DOI：
10.1084/jem.20080421
发表时间：
2008-09-29
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Getts DR;Terry RL;Getts MT;Müller M;Rana S;Shrestha B;Radford J;Van Rooijen N;Campbell IL;King NJ
通讯作者：
King NJ
影响因子：
2.5
作者：
Alliot, F;Rutin, J;Pessac, B
通讯作者：
Pessac, B
影响因子：
3.2
作者：
Apostolopoulos, J;Chisholm, LJ;Sandrin, MS
通讯作者：
Sandrin, MS
影响因子：
3.7
作者：
BALL, AO;BEARD, CW;SPINDLER, KR
通讯作者：
SPINDLER, KR
DOI：
10.1016/0169-328x(90)90003-v
发表时间：
1990-06-01
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
CRAY, C;KEANE, RW;LEVY, RB
通讯作者：
LEVY, RB