Acetylcholinesterase inhibitory, antioxidant and phytochemical properties of selected medicinal plants of the Lamiaceae family.
Acetylcholinesterase inhibitory, antioxidant and phytochemical properties of selected medicinal plants of the Lamiaceae family.
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DOI：
10.3390/molecules19010767
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发表时间：
2014-01-09
期刊：
影响因子：
--
通讯作者：
Brantner AH
中科院分区：
文献类型：
--
作者：
Vladimir-Knežević S;Blažeković B;Kindl M;Vladić J;Lower-Nedza AD;Brantner AH
本研究旨在评估克罗地亚野生唇形科药用植物的乙酰胆碱酯酶（AChE）抑制和抗氧化活性。使用埃尔曼比色测定法，所有测试的乙醇提取物及其羟基肉桂酸成分均以剂量依赖性方式证明了体外 AChE 抑制特性。 1 mg/mL 的薄荷、M. longifolia、Salvia officinalis、Satureja montana、Teucrium arduini、T. chamaedrys、T. montanum、T. polium 和 Thymus vulgaris 的提取物对 AChE 表现出很强的抑制活性。通过DPPH·清除活性和总抗氧化能力测定来评估所研究的唇形科物种的抗氧化潜力，并与羟基肉桂酸和维生素E进行比较。通过分光光度法测定，提取物的总羟基肉桂酸衍生物含量差异很大。发现迷迭香酸是大多数研究的药用植物（通过 RP-HPLC）的主要成分，并且对其 AChE 抑制和抗氧化特性具有重大影响，Teucrium 物种除外。这些发现表明，唇形科物种是各种天然乙酰胆碱酯酶抑制剂和抗氧化剂的丰富来源，可用于预防和治疗阿尔茨海默氏症和其他相关疾病。
The present study aimed to evaluate acetylcholinesterase (AChE) inhibitory and antioxidant activities of Lamiaceae medicinal plants growing wild in Croatia. Using Ellman’s colorimetric assay all tested ethanolic extracts and their hydroxycinnamic acid constituents demonstrated in vitro AChE inhibitory properties in a dose dependent manner. The extracts of Mentha x piperita, M. longifolia, Salvia officinalis, Satureja montana, Teucrium arduini, T. chamaedrys, T. montanum, T. polium and Thymus vulgaris at 1 mg/mL showed strong inhibitory activity against AChE. The antioxidant potential of the investigated Lamiaceae species was assessed by DPPH• scavenging activity and total antioxidant capacity assays, in comparison with hydroxycinnamic acids and trolox. The extracts differed greatly in their total hydroxycinnamic derivatives content, determined spectrophotometrically. Rosmarinic acid was found to be the predominant constituent in most of the investigated medicinal plants (by RP-HPLC) and had a substantial influence on their AChE inhibitory and antioxidant properties, with the exception of Teucrium species. These findings indicate that Lamiaceae species are a rich source of various natural AChE inhibitors and antioxidants that could be useful in the prevention and treatment of Alzheimer’s and other related diseases.
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影响因子：
5.4
作者：
Ferreira, A.;Proenca, C.;Araujo, M. E. M.
通讯作者：
Araujo, M. E. M.
影响因子：
5.4
作者：
Fernandez, L. F.;Palomino, O. M.;Frutos, G.
通讯作者：
Frutos, G.
影响因子：
3.8
作者：
Marin, PD;Grayer, RJ;Harborne, JB
通讯作者：
Harborne, JB
影响因子：
5.3
作者：
Biran Y;Masters CL;Barnham KJ;Bush AI;Adlard PA
通讯作者：
Adlard PA
影响因子：
6.1
作者：
Bai, Naisheng;He, Kan;Ho, Chi-Tang
通讯作者：
Ho, Chi-Tang