Noise exposure-induced enhancement of auditory cortex response and changes in gene expression.
Noise exposure-induced enhancement of auditory cortex response and changes in gene expression.
复制标题
噪声暴露引起的听觉皮层反应的增强和基因表达的变化。
DOI：
10.1016/j.neuroscience.2008.07.040
复制
发表时间：
2008-10-02
期刊：
影响因子：
3.3
通讯作者：
Salvi, R.
中科院分区：
文献类型：
--
作者：
Sun, W.;Zhang, L.;Lu, J.;Yang, G.;Laundrie, E.;Salvi, R.
噪声暴露是导致听力损失的最常见原因之一。越来越多的证据表明，噪声引起的外周听力损失也可引起中枢听觉系统的功能变化。然而，噪声暴露引起的中枢听觉系统的生理和生物学变化知之甚少。为了解决这些问题，神经生理记录从清醒大鼠的听觉皮层（AC）使用长期植入电极之前和之后的声过度刺激。此外，聚焦基因芯片和定量实时PCR被用来确定在AC中的基因表达的变化。单耳噪声暴露（120 dB SPL，1 h）显着提高暴露耳的听阈，并诱导一个短暂的增强后4 h的AC响应幅度记录从非暴露耳噪声暴露。这种增加的皮层神经反应幅度与上调编码热休克蛋白（HSP）27 kDa和70 kDa的基因后，几个小时的噪声暴露。这些结果提示噪声暴露可引起AC快速的生理变化，这种变化可能与HSP表达的变化有关。
Noise exposure is one of the most common causes of hearing loss. There is growing evidence suggesting that noise induced peripheral hearing loss can also induce functional changes in the central auditory system. However, the physiological and biological changes in the central auditory system induced by noise exposure are poorly understood. To address these issues, neurophysiological recordings were made from the auditory cortex (AC) of awake rats using chronically implanted electrodes before and after acoustic overstimulation. In addition, focused gene microarrays and quantitative real-time PCR were used to identify changes in gene expression in the AC. Monaural noise exposure (120 dB SPL, 1 h) significantly elevated hearing threshold on the exposed ear and induced a transient enhancement on the AC response amplitude 4 h after the noise exposure recorded from the unexposed ear. This increase of the cortical neural response amplitude was associated with an upregulation of genes encoding heat shock protein (HSP) 27 kDa and 70 kDa after several hours of the noise exposure. These results suggest that noise exposure can induce a fast physiological change in the AC which may be related to the changes of HSP expressions.
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影响因子：
1.7
作者：
Katano, H;Masago, A;Yamada, K
通讯作者：
Yamada, K
影响因子：
0.7
作者：
Mokrushin, AA;Pavlinova, LI;Plekhanov, AY
通讯作者：
Plekhanov, AY
影响因子：
4.2
作者：
Säljö, A;Bao, F;Haglid, KG
通讯作者：
Haglid, KG
影响因子：
3.4
作者：
Cromheecke, M;Piers, BA;Hoekstra, HJ
通讯作者：
Hoekstra, HJ
DOI：
10.1159/000027764
发表时间：
2000-11-01
期刊：
ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES
影响因子：
--
作者：
Aarnisalo, AA;Pirvola, U;Ylikoski, J
通讯作者：
Ylikoski, J