Distinct medial temporal networks encode surprise during motivation by reward versus punishment.
Distinct medial temporal networks encode surprise during motivation by reward versus punishment.
复制标题
DOI：
10.1016/j.nlm.2016.01.018
复制
发表时间：
2016-10
影响因子：
2.7
通讯作者：
Adcock, R. Alison
中科院分区：
文献类型：
--
作者：
Murty, Vishnu P.;LaBar, Kevin S.;Adcock, R. Alison
适应性动机行为需要对环境的预测性内部表征，而令人惊讶的事件是编码环境新表征的指示。内侧颞叶记忆系统，包括海马体和周围的皮层，编码令人惊讶的事件，并受到动机状态的影响。因为行为反映了个体的目标，我们调查了动机效价（即，追求奖励与避免惩罚）也影响令人惊讶的事件的神经和记忆编码。在功能性磁共振成像（fMRI）中，参与者在追求奖励或避免惩罚的过程中遇到了感知上意想不到的事件。尽管各组的动机水平相似，但奖励和惩罚促进了不同内侧颞叶区域对令人惊讶的事件的处理。而在奖励动机，知觉的惊喜增强激活海马，在惩罚动机的惊喜，而不是增强激活海马旁皮质。此外，我们发现，奖励动机促进海马耦合腹内侧PFC，而惩罚动机促进海马旁皮质耦合眶额皮质。行为上，扫描后的测试表明，奖励，而不是惩罚，动机导致更大的记忆选择性的惊人的事件，在追求目标。总之，这些发现表明，参与奖励和惩罚的预期的神经调节系统的目标内侧颞叶的独立组成部分，调制内侧颞叶的敏感性和连通性。因此，奖励和惩罚动机会产生不同的学习神经背景，并对如何将惊喜纳入环境的预测助记模型产生不同的后果。
Adaptive motivated behavior requires predictive internal representations of the environment, and surprising events are indications for encoding new representations of the environment. The medial temporal lobe memory system, including the hippocampus and surrounding cortex, encodes surprising events and is influenced by motivational state. Because behavior reflects the goals of an individual, we investigated whether motivational valence (i.e., pursuing rewards versus avoiding punishments) also impacts neural and mnemonic encoding of surprising events. During functional magnetic resonance imaging (fMRI), participants encountered perceptually unexpected events either during the pursuit of rewards or avoidance of punishments. Despite similar levels of motivation across groups, reward and punishment facilitated the processing of surprising events in different medial temporal lobe regions. Whereas during reward motivation, perceptual surprises enhanced activation in the hippocampus, during punishment motivation surprises instead enhanced activation in parahippocampal cortex. Further, we found that reward motivation facilitated hippocampal coupling with ventromedial PFC, whereas punishment motivation facilitated parahippocampal cortical coupling with orbitofrontal cortex. Behaviorally, post-scan testing revealed that reward, but not punishment, motivation resulted in greater memory selectivity for surprising events encountered during goal pursuit. Together these findings demonstrate that neuromodulatory systems engaged by anticipation of reward and punishment target separate components of the medial temporal lobe, modulating medial temporal lobe sensitivity and connectivity. Thus, reward and punishment motivation yield distinct neural contexts for learning, with distinct consequences for how surprises are incorporated into predictive mnemonic models of the environment.
登录
查看更多内容
影响因子：
16.2
作者：
Daw ND;Gershman SJ;Seymour B;Dayan P;Dolan RJ
通讯作者：
Dolan RJ
影响因子：
4.3
作者：
Delgado MR;Jou RL;Phelps EA
通讯作者：
Phelps EA
影响因子：
3
作者：
Carter RM;Macinnes JJ;Huettel SA;Adcock RA
通讯作者：
Adcock RA
影响因子：
16.2
作者：
Bromberg-Martin, Ethan S.;Matsumoto, Masayuki;Hikosaka, Okihide
通讯作者：
Hikosaka, Okihide
影响因子：
4.8
作者：
Bauch, Eva M.;Rausch, Vanessa H.;Bunzeck, Nico
通讯作者：
Bunzeck, Nico