The RST and PARP-like domain containing SRO protein family: analysis of protein structure, function and conservation in land plants.
The RST and PARP-like domain containing SRO protein family: analysis of protein structure, function and conservation in land plants.
复制标题
DOI：
10.1186/1471-2164-11-170
复制
发表时间：
2010-03-12
期刊：
影响因子：
4.4
通讯作者：
Kangasjärvi J
中科院分区：
文献类型：
--
作者：
Jaspers P;Overmyer K;Wrzaczek M;Vainonen JP;Blomster T;Salojärvi J;Reddy RA;Kangasjärvi J
SROs（类似于RCD-ONE）是一组植物特异性蛋白，在逆境适应和发育中具有重要功能。它们包含poly（adp -核糖）聚合酶（PARP）结构域的催化核心和c端RST （RCD-SRO-TAF4）结构域。除了这些结构域，一些，但不是全部，sro包含一个n端WWE结构域。sro存在于所有分析的陆地植物中，序列分析区分了两个结构不同的群体；隐子和单子体只有I族sro，而双子体也有II族sro。一类sro具有n端WWE结构域（PS50918），而二类sro缺乏WWE结构域。I族结构域结构广泛存在于远至人类的生物体中（例如HsPARP11）。我们为SRO家族提出一个统一的命名法。sro能够通过c端RST结构域与转录因子相互作用，但它们本身通常不受转录水平的调控。sro最保守的特征是聚（adp -核糖）聚合酶（PS51059）结构域的催化核心。然而，SRO PARP结构域折叠结构的生物信息学分析和AtRCD1的生化分析表明，SRO不具有adp -核糖基转移酶活性。sro是一个高度保守的植物特异性蛋白家族。RST结构域的序列分析表明该区域存在高度保存的蛋白质结构。这可能对功能守恒有影响。我们认为，尽管存在PARP结构域的催化核心，sro不具有adp -核糖基转移酶活性。然而，sro的功能对植物至关重要，可能与转录因子调控和复合物形成有关。
The SROs (SIMILAR TO RCD-ONE) are a group of plant-specific proteins which have important functions in stress adaptation and development. They contain the catalytic core of the poly(ADP-ribose) polymerase (PARP) domain and a C-terminal RST (RCD-SRO-TAF4) domain. In addition to these domains, several, but not all, SROs contain an N-terminal WWE domain. SROs are present in all analyzed land plants and sequence analysis differentiates between two structurally distinct groups; cryptogams and monocots possess only group I SROs whereas eudicots also contain group II. Group I SROs possess an N-terminal WWE domain (PS50918) but the WWE domain is lacking in group II SROs. Group I domain structure is widely represented in organisms as distant as humans (for example, HsPARP11). We propose a unified nomenclature for the SRO family. The SROs are able to interact with transcription factors through the C-terminal RST domain but themselves are generally not regulated at the transcriptional level. The most conserved feature of the SROs is the catalytic core of the poly(ADP-ribose) polymerase (PS51059) domain. However, bioinformatic analysis of the SRO PARP domain fold-structure and biochemical assays of AtRCD1 suggested that SROs do not possess ADP-ribosyl transferase activity. The SROs are a highly conserved family of plant specific proteins. Sequence analysis of the RST domain implicates a highly preserved protein structure in that region. This might have implications for functional conservation. We suggest that, despite the presence of the catalytic core of the PARP domain, the SROs do not possess ADP-ribosyl transferase activity. Nevertheless, the function of SROs is critical for plants and might be related to transcription factor regulation and complex formation.
登录
查看更多内容
影响因子：
6.9
作者：
Bechtold, Ulrike;Richard, Odile;Mullineaux, Philip M.
通讯作者：
Mullineaux, Philip M.
DOI：
10.1073/pnas.0604711103
发表时间：
2006-12-05
影响因子：
11.1
作者：
Katiyar-Agarwal, Surekha;Zhu, Jianhua;Zhu, Jian-Kang
通讯作者：
Zhu, Jian-Kang
Wolf Psort：蛋白质定位预测因子。
影响因子：
14.9
作者：
Horton, Paul;Park, Keun-Joon;Obayashi, Takeshi;Fujita, Naoya;Harada, Hajime;Adams-Collier, C J;Nakai, Kenta
通讯作者：
Nakai, Kenta
影响因子：
3.8
作者：
de Marco, A;Vigh, L;Goloubinoff, P
通讯作者：
Goloubinoff, P
影响因子：
7.2
作者：
Ahlfors, Reetta;Brosche, Mikael;Kangasjarvi, Jaakko
通讯作者：
Kangasjarvi, Jaakko