Solid cancer incidence other than lung, liver and bone in Mayak workers: 1948-2004.
Solid cancer incidence other than lung, liver and bone in Mayak workers: 1948-2004.
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DOI：
10.1038/bjc.2013.543
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发表时间：
2013-10-01
影响因子：
8.8
通讯作者：
Harrison, J. D.
中科院分区：
文献类型：
--
作者：
Hunter, N.;Kuznetsova, I. S.;Labutina, E. V.;Harrison, J. D.
对 Mayak Production Association (PA) 队列中的癌症发病率进行了分析，首次调查外部伽马射线和内部钚暴露是否与除肺癌、肝癌和骨癌（其他实体癌）之外的实体癌发病率升高有关。该队列包括 22 366 名在 1948 年至 1982 年间首次就业的男女工人。在截至 2004 年的随访期间，总共登记了 1447 例其他实体癌症病例。泊松回归用于估计每单位累积暴露于钚和外部伽马射线的超额相对风险 (ERR)。研究发现，外部伽马射线累积暴露与其他实体癌的发病率之间存在微弱关联（ERR/Gy=0.07；95%置信区间（CI）：0.01-0.15），但在调整内部钚暴露后，这种关联失去了显着性。没有迹象表明钚暴露与其他实体癌有任何关联。在 16 个单独的癌症部位中，唇癌与外部暴露（ERR/Gy=1.74；95% CI：0.37；6.71）以及胰腺癌钚暴露（ERR/Gy=1.58；95% CI；0.17；4.77）存在统计学显着相关性。这项针对玛雅克工人的研究并未提供其他实体癌症风险增加的证据。观察到的唇癌和胰腺癌风险增加应谨慎对待，因为相关数据数量有限，而且观察结果可能只是偶然。
Cancer incidence in the Mayak Production Association (PA) cohort was analysed to investigate for the first time whether external gamma-ray and internal plutonium exposure are associated with raised incidence of solid cancers other than lung, liver and bone (other solid cancers). The cohort includes 22 366 workers of both sexes who were first employed between 1948 and 1982. A total of 1447 cases of other solid cancers were registered in the follow-up period until 2004. The Poisson regression was used to estimate the excess relative risk (ERR) per unit of cumulative exposure to plutonium and external gamma-ray. A weak association was found between cumulative exposure to external gamma-ray and the incidence of other solid cancers (ERR/Gy=0.07; 95% confidence intervals (CIs): 0.01–0.15), but this association lost its significance after adjusting for internal plutonium exposure. There was no indication of any association with plutonium exposure for other solid cancers. Among 16 individual cancer sites, there was a statistically significant association with external exposure for lip cancer (ERR/Gy=1.74; 95% CI: 0.37; 6.71) and with plutonium exposure for pancreatic cancer (ERR/Gy=1.58; 95% CI; 0.17; 4.77). This study of Mayak workers does not provide evidence of an increased risk of other solid cancers. The observed increase in the risk of cancer of the lip and pancreas should be treated with caution because of the limited amount of relevant data and because the observations may be simply due to chance.
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影响因子：
8.8
作者：
通讯作者：
--
影响因子：
2.2
作者：
Labutina, E. V.;Kuznetsova, I. S.;Koshurnikova, N. A.
通讯作者：
Koshurnikova, N. A.
影响因子：
3.4
作者：
Cardis, E.;Vrijheid, M.;Veress, K.
通讯作者：
Veress, K.
影响因子：
3.4
作者：
Preston, D. L.;Krestinina, L. Yu;Gilbert, E. S.
通讯作者：
Gilbert, E. S.
影响因子：
2.2
作者：
Azizova, Tamara V.;Muirhead, Colin R.;O'Hagan, Jacqueline A.
通讯作者：
O'Hagan, Jacqueline A.