Slowing down: age-related neurobiological predictors of processing speed.
Slowing down: age-related neurobiological predictors of processing speed.
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DOI：
10.3389/fnins.2011.00025
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发表时间：
2011
影响因子：
4.3
通讯作者：
Eckert MA
中科院分区：
文献类型：
--
作者：
Eckert MA
处理速度或执行任务的速度是与年龄相关的认知能力下降的有力预测因素，也是老年人独立性的指标。这篇综述研究了与年龄相关的处理速度变化的神经生物学预测因素的证据，这在一定程度上是由我们基于来源的形态测量发现所指导的，即额叶和小脑灰质的独特模式可以预测与年龄相关的处理速度变化。这些结果与现有的关于与年龄相关的处理速度变化的形态学预测因素的文献一起表明，特定的神经系统会经历衰退，从而导致处理速度变慢。未来对处理速度依赖性神经系统的研究对于确定处理速度变化的病因以及开发缓解与年龄相关的认知功能逐渐下降和增强健康认知衰老的干预措施非常重要。
Processing speed, or the rate at which tasks can be performed, is a robust predictor of age-related cognitive decline and an indicator of independence among older adults. This review examines evidence for neurobiological predictors of age-related changes in processing speed, which is guided in part by our source based morphometry findings that unique patterns of frontal and cerebellar gray matter predict age-related variation in processing speed. These results, together with the extant literature on morphological predictors of age-related changes in processing speed, suggest that specific neural systems undergo declines and as a result slow processing speed. Future studies of processing speed – dependent neural systems will be important for identifying the etiologies for processing speed change and the development of interventions that mitigate gradual age-related declines in cognitive functioning and enhance healthy cognitive aging.
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DOI：
10.1098/rstb.2005.1634
发表时间：
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影响因子：
6.3
作者：
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