Dietary magnesium intake improves insulin resistance among non-diabetic individuals with metabolic syndrome participating in a dietary trial.
Dietary magnesium intake improves insulin resistance among non-diabetic individuals with metabolic syndrome participating in a dietary trial.
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作者：
Wang J;Persuitte G;Olendzki BC;Wedick NM;Zhang Z;Merriam PA;Fang H;Carmody J;Olendzki GF;Ma Y
许多横断面研究显示膳食镁和胰岛素抵抗之间存在负相关，但很少有纵向研究检查通过食物摄入镁的推荐膳食允许量（RDA）的能力及其对代谢综合征（MetS）参与者胰岛素抵抗的影响。饮食干预研究在234名MetS患者中检查了这个问题。在基线、6个月和12个月时，使用24小时饮食回忆评估镁摄入量。在每个时间点收集空腹血糖和胰岛素水平;通过稳态模型评估（HOMA-IR）估计胰岛素抵抗。使用调整协变量的线性混合模型评估镁摄入量和HOMA-IR之间的关系。基线镁摄入量为287 ± 93 mg/天（平均值±标准差），HOMA-IR、空腹血糖和空腹胰岛素分别为3.7 ± 3.5、99 ± 13 mg/dL和15 ± 13 μU/mL。在基线、6个月和12个月时，23.5%、30.4%和27.7%的患者符合镁的RDA。经多因素校正后，镁摄入量与胰岛素抵抗的代谢标志物呈负相关（P < 0.01）。此外，镁摄入量最高四分位数的参与者随着时间推移HOMA-IR升高（>3.6）的可能性比最低四分位数的参与者低71%[比值比（OR）：0.29; 95%置信区间（CI）：0.12，0.72]。对于符合镁RDA的个体，随时间推移HOMA-IR升高的多变量校正OR为0.37（95% CI：0.18，0.77）。这些研究结果表明，膳食镁摄入量是不充分的非糖尿病个体代谢综合征，并建议增加膳食镁，以满足RDA对胰岛素抵抗有保护作用。
Many cross-sectional studies show an inverse association between dietary magnesium and insulin resistance, but few longitudinal studies examine the ability to meet the Recommended Dietary Allowance (RDA) for magnesium intake through food and its effect on insulin resistance among participants with metabolic syndrome (MetS). The dietary intervention study examined this question in 234 individuals with MetS. Magnesium intake was assessed using 24-h dietary recalls at baseline, 6, and 12 months. Fasting glucose and insulin levels were collected at each time point; and insulin resistance was estimated by the homeostasis model assessment (HOMA-IR). The relation between magnesium intake and HOMA-IR was assessed using linear mixed models adjusted for covariates. Baseline magnesium intake was 287 ± 93 mg/day (mean ± standard deviation), and HOMA-IR, fasting glucose and fasting insulin were 3.7 ± 3.5, 99 ± 13 mg/dL, and 15 ± 13 μU/mL, respectively. At baseline, 6-, and 12-months, 23.5%, 30.4%, and 27.7% met the RDA for magnesium. After multivariate adjustment, magnesium intake was inversely associated with metabolic biomarkers of insulin resistance (P < 0.01). Further, the likelihood of elevated HOMA-IR (>3.6) over time was 71% lower [odds ratio (OR): 0.29; 95% confidence interval (CI): 0.12, 0.72] in participants in the highest quartile of magnesium intake than those in the lowest quartile. For individuals meeting the RDA for magnesium, the multivariate-adjusted OR for high HOMA-IR over time was 0.37 (95% CI: 0.18, 0.77). These findings indicate that dietary magnesium intake is inadequate among non-diabetic individuals with MetS and suggest that increasing dietary magnesium to meet the RDA has a protective effect on insulin resistance.
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影响因子：
4
作者：
Merriam, Philip A.;Ma, Yunsheng;Pagoto, Sherry L.
通讯作者：
Pagoto, Sherry L.
影响因子：
7.2
作者：
Guerrero-Romero, F;Tamez-Perez, HE;Rodríguez-Morán, M
通讯作者：
Rodríguez-Morán, M
DOI：
10.1080/07315724.2006.10719563
发表时间：
2006-12-01
影响因子：
3.5
作者：
Rumawas, Marcella E.;McKeown, Nicola M.;Jacques, Paul F.
通讯作者：
Jacques, Paul F.
影响因子：
7.1
作者：
Hunt, Curtiss D.;Johnson, LuAnn K.
通讯作者：
Johnson, LuAnn K.
DOI：
10.3945/jn.111.142257
发表时间：
2011-10
期刊：
The Journal of nutrition
影响因子：
--
作者：
Fulgoni VL 3rd;Keast DR;Bailey RL;Dwyer J
通讯作者：
Dwyer J