Associations between health effects and particulate matter and black carbon in subjects with respiratory disease.
Associations between health effects and particulate matter and black carbon in subjects with respiratory disease.
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DOI：
10.1289/ehp.8153
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发表时间：
2005-12
影响因子：
10.4
通讯作者：
Lippmann M
中科院分区：
文献类型：
--
作者：
Jansen KL;Larson TV;Koenig JQ;Mar TF;Fields C;Stewart J;Lippmann M
在华盛顿州西雅图，我们测量了16名患有哮喘或慢性阻塞性肺疾病(COPD)的老年患者的呼出一氧化氮(FeNO)、肺活量、血压、血氧饱和度(SaO2)和脉率。连续12天每天收集数据。我们同时在一个中央室外站点以及受试者住宅内外收集了PM10和PM2.5(分别为颗粒物≤10μm或≤2.5μm)的过滤器样本。还收集了个人PM10过滤器样本。分析了所有滤光片的质量和光吸收。我们使用随机截距的线性混合效应模型，控制了年龄、环境相对湿度和环境温度，分析了健康结果和空气污染指标之间的受试者内关联。在7名哮喘患者中，24小时室外PM10和PM2.5平均浓度每增加10μg/m~3，FeNO浓度分别增加5.9ppb(95%可信区间，2.90-8.9ppb)和4.2ppb(95%可信区间，1.3ppb-7.1ppb)。室外、室内和个人黑碳(BC)每增加1μg/m~3，FeNO分别增加2.3ppb(95%CI，1.1-3.6)、4.0ppb(95%CI，2.0-5.9)和1.2ppb(95%CI，0.2-2.2)。在这些受试者中，PM或BC测量与肺活量、血压、脉率或血氧饱和度的变化之间没有发现显著的关联。这项研究的结果表明，与传统的健康结果相比，FeNO可能是PM暴露的更敏感的标志，并且与颗粒物相关的BC有助于检查PM的主要燃烧成分与健康结果之间的关联。
We measured fractional exhaled nitric oxide (FENO), spirometry, blood pressure, oxygen saturation of the blood (SaO2), and pulse rate in 16 older subjects with asthma or chronic obstructive pulmonary disease (COPD) in Seattle, Washington. Data were collected daily for 12 days. We simultaneously collected PM10 and PM2.5 (particulate matter ≤10 μm or ≤2.5 μm, respectively) filter samples at a central outdoor site, as well as outside and inside the subjects’ homes. Personal PM10 filter samples were also collected. All filters were analyzed for mass and light absorbance. We analyzed within-subject associations between health outcomes and air pollution metrics using a linear mixed-effects model with random intercept, controlling for age, ambient relative humidity, and ambient temperature. For the 7 subjects with asthma, a 10 μg/m3 increase in 24-hr average outdoor PM10 and PM2.5 was associated with a 5.9 [95% confidence interval (CI), 2.9–8.9] and 4.2 ppb (95% CI, 1.3–7.1) increase in FENO, respectively. A 1 μg/m3 increase in outdoor, indoor, and personal black carbon (BC) was associated with increases in FENO of 2.3 ppb (95% CI, 1.1–3.6), 4.0 ppb (95% CI, 2.0–5.9), and 1.2 ppb (95% CI, 0.2–2.2), respectively. No significant association was found between PM or BC measures and changes in spirometry, blood pressure, pulse rate, or SaO2 in these subjects. Results from this study indicate that FENO may be a more sensitive marker of PM exposure than traditional health outcomes and that particle-associated BC is useful for examining associations between primary combustion constituents of PM and health outcomes.
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影响因子：
10.4
作者：
Dockery, DW
通讯作者：
Dockery, DW
影响因子：
10.4
作者：
Koenig, J Q;Jansen, K;Mar, T F;Lumley, T;Kaufman, J;Trenga, C A;Sullivan, J;Liu, L-J S;Shapiro, G G;Larson, T V
通讯作者：
Larson, T V
影响因子：
10.4
作者：
Gold DR;Litonjua AA;Zanobetti A;Coull BA;Schwartz J;MacCallum G;Verrier RL;Nearing BD;Canner MJ;Suh H;Stone PH
通讯作者：
Stone PH
DOI：
10.1007/s00420-002-0320-x
发表时间：
2002-06-01
影响因子：
3
作者：
Fischer, PH;Steerenberg, PA;van Amsterdam, JGC
通讯作者：
van Amsterdam, JGC
DOI：
10.1164/ajrccm.152.2.7633728
发表时间：
1995-08-01
影响因子：
24.7
作者：
HANKINSON, JL;CRAPO, RO
通讯作者：
CRAPO, RO