Reduced white matter integrity and verbal fluency impairment in young adults with bipolar disorder: a diffusion tensor imaging study.
Reduced white matter integrity and verbal fluency impairment in young adults with bipolar disorder: a diffusion tensor imaging study.
复制标题
躁郁症的年轻人的白质完整性和言语流利性障碍降低：一项扩散张量成像研究。
DOI：
10.1016/j.jpsychires.2015.01.008
复制
发表时间：
2015-03
影响因子：
4.8
通讯作者：
Soares, Jair C.
中科院分区：
文献类型：
--
作者：
Bauer, Isabelle E.;Ouyang, Austin;Mwangi, Benson;Sanches, Marsal;Zunta-Soares, Giovana B.;Keefe, Richard S. E.;Huang, Hao;Soares, Jair C.
临床证据表明，双相情感障碍（BD）的特点是白色物质（WM）的微结构异常。然而，人们对这些异常的生物学机制及其与认知功能的关系知之甚少。49例成人BD患者（M ± SD）：29.27 ± 7.92岁;男性17例，女性32例; BD-I型34例，BD-II型10例，BD-NOS型5例）和28例年龄匹配的正常受试者（M ± SD）：29.19 ± 7.35岁;男性10例，女性18例）接受了弥散张量成像（DTI）。使用全脑基于束的空间统计（TBSS）作为FMRIB软件库的一部分计算DTI指标。WM相干性（分数各向异性-FA）和轴突结构（平均，轴向和径向扩散-MD，AD和RD）的措施被用来表征边缘，连合，联合和投影纤维束的微结构改变。所有参与者都进行了情感障碍认知的简要评估（BAC-A）。BD患者在语言流畅性任务上表现不佳，并且在内囊的晶状体后部分、上级和前放射冠以及胼胝体内表现出大簇改变的FA、RD和MD值。左侧IFOF和小产钳的FA值增加与语言流畅性评分呈正相关。皮质脊髓束和小产钳的RD参数改变与视力下降相关。报告的言语流畅性缺陷和FA，RD和MD改变WM结构是潜在的认知和神经标记的BD。异常RD值可能与进行性脱髓鞘相关。
Clinical evidence shows that bipolar disorder (BD) is characterized by white matter (WM) microstructural abnormalities. However, little is known about the biological mechanisms associated with these abnormalities and their relationship with cognitive functioning. 49 adult BD patients ((M±SD): 29.27 ± 7.92 years; 17 males, 32 females; 34 BD-I, 10 BD-II, and 5 BD-NOS) and 28 age-matched normal subjects ((M±SD): 29.19 ± 7.35 years; 10 males and 18 females) underwent diffusion tensor imaging (DTI) imaging. DTI metrics were computed using whole-brain tract-based spatial statistics (TBSS) as part of the FMRIB Software Library. Measures of WM coherence (fractional anisotropy - FA) and axonal structure (mean, axial and radial diffusivity - MD, AD and RD) were employed to characterize the microstructural alterations in the limbic, commissural, association and projection fiber tracts. All participants performed the Brief Assessment of Cognition for Affective disorders (BAC-A). BD patients performed poorly on verbal fluency tasks and exhibited large clusters of altered FA, RD and MD values within the retrolenticular part of the internal capsule, the superior and anterior corona radiata, and the corpus callosum. Increased FA values in the left IFOF and the forceps minor correlated positively with verbal fluency scores. Altered RD parameters in the corticospinal tract and the forceps minor were associated with reduced visuomotor abilities. The reported verbal fluency deficits and FA, RD and MD alterations in WM structures are potential cognitive and neural markers of BD. Abnormal RD values may be associated with progressive demyelination.
登录
查看更多内容
影响因子：
3.7
作者：
Blumenfeld-Katzir T;Pasternak O;Dagan M;Assaf Y
通讯作者：
Assaf Y
影响因子：
6.7
作者：
Albus, M;Hubmann, W;Mohr, F
通讯作者：
Mohr, F
影响因子：
3.3
作者：
Heng, Serene;Song, Allen W.;Sim, Kang
通讯作者：
Sim, Kang
影响因子：
8.2
作者：
Brenhouse, Heather C.;Andersen, Susan L.
通讯作者：
Andersen, Susan L.
影响因子：
1.7
作者：
Foland, Lara C.;Altshuler, Lori L.;Thompson, Paul M.
通讯作者：
Thompson, Paul M.