JaponicusDB: rapid deployment of a model organism database for an emerging model species.

JaponicusDB: rapid deployment of a model organism database for an emerging model species.
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DOI:
10.1093/genetics/iyab223
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发表时间:
2022-04-04
期刊:
影响因子:
3.3
通讯作者:
Wood, Valerie
Wood, Valerie
中科院分区:
生物学2区
文献类型:
--
作者:
Rutherford, Kim M.;Harris, Midori A.;Oliferenko, Snezhana;Wood, Valerie

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分裂酵母日本裂糖酵母(Schizosaccharomyces japonicus)最近成为研究基本细胞过程进化的一个强大系统,利用了日本裂糖酵母(s.japonicus)与相关的已建立的模式pombe裂糖酵母(Schizosaccharomyces pombe)之间的相似性和关键差异。我们已经部署了最初为PomBase开发的开源模块化代码和工具,S. pombe模型生物数据库(MOD),以创建JaponicusDB (www.japonicusdb.org),这是一个专门用于S. japonicus的新MOD。通过提供一个中央资源,随时可以访问不断增长的实验数据,基于本体的管理,无缝浏览和查询,以及将新数据与现有知识集成的能力,JaponicusDB对裂变酵母生物学家的支持远远超过任何其他来源的s.a japonicus数据。因此,JaponicusDB使日本血吸虫研究人员能够充分发挥研究新出现的模式物种的潜力,并说明利用可重用的PomBase代码构建一个全面的、社区可维护的物种相关知识库的广泛应用能力和实用性。
The fission yeast Schizosaccharomyces japonicus has recently emerged as a powerful system for studying the evolution of essential cellular processes, drawing on similarities as well as key differences between S. japonicus and the related, well-established model Schizosaccharomyces pombe. We have deployed the open-source, modular code and tools originally developed for PomBase, the S. pombe model organism database (MOD), to create JaponicusDB (www.japonicusdb.org), a new MOD dedicated to S. japonicus. By providing a central resource with ready access to a growing body of experimental data, ontology-based curation, seamless browsing and querying, and the ability to integrate new data with existing knowledge, JaponicusDB supports fission yeast biologists to a far greater extent than any other source of S. japonicus data. JaponicusDB thus enables S. japonicus researchers to realize the full potential of studying a newly emerging model species and illustrates the widely applicable power and utility of harnessing reusable PomBase code to build a comprehensive, community-maintainable repository of species-relevant knowledge.
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