Sex differences in the brain: Implications for behavioral and biomedical research.
Sex differences in the brain: Implications for behavioral and biomedical research.
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DOI：
10.1016/j.neubiorev.2017.07.005
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发表时间：
2018-03
影响因子：
8.2
通讯作者：
Frick KM
中科院分区：
文献类型：
--
作者：
Choleris E;Galea LAM;Sohrabji F;Frick KM
男性和女性之间的生物差异存在于多个层面。然而，女性在行为神经科学研究中的代表性太低，这阻碍了神经生物学和行为中潜在性别差异的研究。这篇综述着重于社会行为、记忆、情绪和脑损伤恢复的神经生物学中的性别差异研究，特别强调雌激素在调节前脑功能中的作用。这项工作由作者在2016年国际行为神经科学学会会议上提出，强调了几种哺乳动物物种的不同方法，其中性别差异不仅被记录在案，而且还成为理解其背后机制基础的重点。这些信息可以为读者提供有用的实验工具，通过授权要求（例如美国的国立卫生研究院和加拿大的加拿大卫生研究院）或建议（例如欧洲的地平线2020）将两性纳入生物医学研究的机构，成功地解决最近出台的法规。
Biological differences between males and females are found at multiple levels. However, females have too often been under-represented in behavioral neuroscience research, which has stymied the study of potential sex differences in neurobiology and behavior. This review focuses on the study of sex differences in the neurobiology of social behavior, memory, emotions, and recovery from brain injury, with particular emphasis on the role of estrogens in regulating forebrain function. This work, presented by the authors at the 2016 meeting of the International Behavioral Neuroscience Society, emphasizes varying approaches from several mammalian species in which sex differences have not only been documented, but also become the focus of efforts to understand the mechanistic basis underlying them. This information may provide readers with useful experimental tools to successfully address recently introduced regulations by granting agencies that either require (e.g. the National Institutes of Health in the United States and the Canadian Institutes of Health Research in Canada) or recommend (e.g. Horizon 2020 in Europe) the inclusion of both sexes in biomedical research.
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影响因子：
3.3
作者：
Barker, J. M.;Galea, L. A. M.
通讯作者：
Galea, L. A. M.
影响因子：
8.2
作者：
BLANCHARD, DC;SHEPHERD, JK;BLANCHARD, RJ
通讯作者：
BLANCHARD, RJ
影响因子：
2.5
作者：
Adkins-Regan, Elizabeth
通讯作者：
Adkins-Regan, Elizabeth
影响因子：
3.5
作者：
Berretti, R.;Santoru, F.;Concas, A.
通讯作者：
Concas, A.
影响因子：
8.2
作者：
Beery AK;Zucker I
通讯作者：
Zucker I