Cell type and circuit modules in the spinal cord.

Cell type and circuit modules in the spinal cord.
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DOI:
10.1016/j.conb.2019.03.003
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发表时间:
2019-06
影响因子:
5.7
通讯作者:
Pfaff SL
Pfaff SL
中科院分区:
医学2区
文献类型:
--
作者:
Osseward PJ 2nd;Pfaff SL

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脊髓包含一个非常不同的相互连接的神经元群体,用于处理体感信息和执行运动。对胚胎脊髓的研究阐明了脊髓神经元特化的基本原理,而成人和出生后的研究则提供了对细胞类型功能和回路的洞察。然而,连接分子定义的亚型与它们的连接性、生理学和功能的首要原则仍然不清楚。这篇综述巩固了最近在脊髓神经元表征方面的工作,考察了单个脊髓神经元类型的分子和空间特征如何与连接性和功能的参考点相关。这篇综述将集中在脊髓神经元亚型是如何组织起来控制小鼠的运动的。
The spinal cord contains an extraordinarily diverse population of interconnected neurons to process somatosensory information and execute movement. Studies of the embryonic spinal cord have elucidated basic principles underlying the specification of spinal cord neurons, while adult and postnatal studies have provided insight into cell type function and circuitry. However, the overarching principles that bridge molecularly defined subtypes with their connectivity, physiology, and function remain unclear. This review consolidates recent work in spinal neuron characterization, examining how molecular and spatial features of individual spinal neuron types relate to the reference points of connectivity and function. This review will focus on how spinal neuron subtypes are organized to control movement in the mouse.
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