Toward integrative genomics study of genetic resistance to Salmonella and Campylobacter intestinal colonization in fowl.
Toward integrative genomics study of genetic resistance to Salmonella and Campylobacter intestinal colonization in fowl.
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DOI：
10.3389/fgene.2012.00261
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发表时间：
2012
影响因子：
3.7
通讯作者：
Beaumont C
中科院分区：
文献类型：
--
作者：
Calenge F;Beaumont C
肠炎沙门氏菌、鼠伤寒沙门氏菌和空肠弯曲菌是欧洲大多数食物中毒病例的原因。这些细菌不会引起鸡的严重疾病症状，但它们很容易通过不易分离的无症状鸡携带者传播。这种动物耐受性不利于食品安全。在这种特殊情况下，增加动物的抵抗力是不够的，因为一些被认为具有抵抗力的动物能够在几周内携带细菌而不表现出疾病症状。我们回顾了旨在评估鸡对感染后几天或几周内沙门氏菌和弯曲杆菌肠道定植的抵抗力的研究。虽然弯曲杆菌定植的基因控制研究才刚刚开始，主要是由于感染方案的技术困难，但沙门氏菌定植的基因研究已经进行了 20 多年。他们最初报告了与沙门氏菌定殖抗性相关的遗传参数的估计，现在的目标是确定在实验品系和商业群体中控制该性状变异的基因组区域。随着高通量基因组学的出现，我们比以往任何时候都更接近于识别控制鸡肠杆菌定植抗性的真正基因。将参与早期肠道定植抵抗的基因与控制感染后几周（即携带状态）细菌持续存在的基因进行比较，应该很快就会凸显出这两种不同表型背后的分子机制之间的差异。比较控制弯曲杆菌和沙门氏菌的基因或基因组区域也将非常有趣，以便评估同时对两种细菌进行选择的可行性。
Salmonella enterica serotypes Enteritidis and Typhimurium and Campylobacter jejuni are responsible for most cases of food poisoning in Europe. These bacteria do not cause severe disease symptoms in chicken, but they are easily propagated by symptomless chicken carriers which cannot be easily isolated. This animal tolerance is detrimental to food safety. In this particular case, increasing animal's resistance is not sufficient, since some animals considered as resistant are able to carry bacteria during several weeks without displaying disease symptoms. We review studies aimed at evaluating the resistance of chicken to Salmonella and Campylobacter intestinal colonization, either a few days or several weeks after infection. While studies of the genetic control of Campylobacter colonization are only beginning, mostly due to technical difficulties in infection protocols, genetic studies of Salmonella colonization have been conducted for now more than 20 years. They have initially reported an estimation of the genetic parameters associated with resistance to Salmonella colonization and are now aimed at identifying the genomic regions controlling variation of this trait in experimental lines and commercial populations. With the advent of high-throughput genomics, we are closer than ever to identify the true genes controlling resistance to Enterobacteria colonization in chicken. The comparison of genes involved in early resistance to intestinal colonization with genes controlling resistance to bacteria persistence several weeks after infection (i.e., carrier-state) should soon highlight the differences between the molecular mechanisms underlying those two distinct phenotypes. It will also be highly interesting to compare the genes or genomic regions controlling Campylobacter and Salmonella, in order to evaluate the feasibility of a selection conducted on both bacteria simultaneously.
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影响因子：
3.7
作者：
Gou Z;Liu R;Zhao G;Zheng M;Li P;Wang H;Zhu Y;Chen J;Wen J
通讯作者：
Wen J
影响因子：
3.1
作者：
Calenge, Fanny;Vignal, Alain;Beaumont, Catherine
通讯作者：
Beaumont, Catherine
影响因子：
3.1
作者：
Hasenstein, Jason R.;Zhang, Guolong;Lamont, Susan J.
通讯作者：
Lamont, Susan J.
影响因子：
1.4
作者：
Sung, HW;Reddy, SM;Fadly, AM
通讯作者：
Fadly, AM
影响因子：
2.4
作者：
Fife, M. S.;Howell, J. S.;Kaiser, P.
通讯作者：
Kaiser, P.