Maternal short sleep duration is associated with increased levels of inflammatory markers at 3 years postpartum.
Maternal short sleep duration is associated with increased levels of inflammatory markers at 3 years postpartum.
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DOI：
10.1016/j.metabol.2010.09.008
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发表时间：
2011-07
影响因子：
9.8
通讯作者：
Mantzoros, Christos S.
中科院分区：
文献类型：
--
作者：
Taveras, Elsie M.;Rifas-Shiman, Sheryl L.;Rich-Edwards, Janet W.;Mantzoros, Christos S.
这项研究的目的是检查产后第一年的妇女睡眠时间短与产后3年炎症的关系。我们研究了479名女性在项目Viva，一个前瞻性队列。在产后6个月和1年，女性报告了她们在24小时内的睡眠时间，我们从中计算出每日睡眠的加权平均值。我们使用多变量中位数回归分析来预测短睡眠时间（≤ 5 h/d v.> 5 h/d）对炎症标志物的影响，例如产后3年时的白细胞介素-6（IL-6）和C-反应蛋白（CRP）。妇女产后第一年的平均（SD）每日睡眠时间为6.7（0.96）小时。在调整了年龄、种族/民族、教育、产次、孕前体重指数、过度妊娠体重增加和分娩时胎龄后，我们发现，与> 5 h/d相比，产后睡眠≤ 5 h/d与IL 6升高相关（β 0.25 pg/mL; 95% CI：0.14，0.43）。尽管产后睡眠≤ 5 h/d似乎也与CRP升高相关（β 0.15 mg/dL; 95% CI：-0.08，0.52），但这些结果未达到统计学显著性。产后第一年睡眠时间短与产后3年促炎标志物IL 6水平升高相关。
The purpose of this study was to examine the association of short sleep duration among women in the first year postpartum with inflammation at 3-years postpartum. We studied 479 women in Project Viva, a prospective cohort. At 6 months and 1 year postpartum, women reported the number of hours they slept in a 24-hour period, from which we calculated a weighted average of daily sleep. We used multivariable median regression analyses to predict the independent effects of short sleep duration (≤ 5 h/d v.> 5 h/d) on markers of inflammation, e.g. interleukin-6 [IL6] and C-reactive protein [CRP] at 3-years postpartum. Women's mean (SD) hours of daily sleep in the first year postpartum was 6.7 (0.96) hours. After adjusting for age, race/ethnicity, education, parity, pre-pregnancy body mass index, excessive gestational weight gain and gestational age at delivery, we found that postpartum sleep ≤ 5 h/d was associated with elevated IL6 (β 0.25 pg/mL; 95% CI: 0.14, 0.43) compared with > 5 h/d. Although postpartum sleep ≤ 5 h/d appeared to also be associated with elevated CRP (β 0.15 mg/dL; 95% CI: −0.08, 0.52), these results did not reach statistical significance. Short sleep duration in the first year postpartum is associated with elevated levels of the pro-inflammatory marker, IL6, at 3-years postpartum.
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DOI：
10.1073/pnas.0808180106
发表时间：
2009-03-17
影响因子：
11.1
作者：
Scheer, Frank A. J. L.;Hilton, Michael F.;Shea, Steven A.
通讯作者：
Shea, Steven A.
影响因子：
16.2
作者：
Ayas, NT;White, DP;Hu, FB
通讯作者：
Hu, FB
影响因子：
120.7
作者：
King, Christopher Ryan;Knutson, Kristen L.;Rathouz, Paul J.;Sidney, Steve;Liu, Kiang;Lauderdale, Diane S.
通讯作者：
Lauderdale, Diane S.
影响因子：
6.9
作者：
Patel, Sanjay R.;Hu, Frank B.
通讯作者：
Hu, Frank B.
影响因子：
5.8
作者：
Vgontzas, AN;Zoumakis, E;Chrousos, GP
通讯作者：
Chrousos, GP