Transcranial slow oscillation stimulation during NREM sleep enhances acquisition of the radial maze task and modulates cortical network activity in rats.
Transcranial slow oscillation stimulation during NREM sleep enhances acquisition of the radial maze task and modulates cortical network activity in rats.
复制标题
DOI：
10.3389/fnbeh.2013.00220
复制
发表时间：
2013
影响因子：
3
通讯作者：
Marshall L
中科院分区：
文献类型：
--
作者：
Binder S;Rawohl J;Born J;Marshall L
慢波睡眠以慢振荡（SO）的发生为特征，对海马体依赖性记忆的巩固起着重要作用。在学习后睡眠期间，经颅微弱的内源性SO频率（SO- tdcs）振荡电流刺激可以提高人类受试者的SO活动，并改善海马依赖记忆的巩固。在这里，我们的目标是复制和扩展这些结果到啮齿动物模型。大鼠在其非活动阶段开始进行参考记忆版本的桡臂迷宫训练，为期12天。在受试者之间的设计中，动物在随后的非快速眼动（NREM）睡眠中，在1小时的时间框架内接受前额叶皮层（PFC）上的SO-tDCS或假刺激。通过脑电图和行为测量，在多个日常会话中应用SO-tDCS会影响皮层网络活动：在脑电图水平上，SO-tDCS增强刺激后上δ (2-4 Hz)活动，因此每天的第一次刺激优先受到影响。此外，从第8天开始，SO-tDCS急剧降低θ波活动，表明对皮质网络有长期影响。行为学上，有诱饵的迷宫手臂的工作记忆在第4天得到了增强，表明任务固有规则的巩固得到了加强，而参考记忆错误在两组之间没有差异。综上所述，我们可以首次在啮齿动物模型中展示非快速眼动睡眠期间SO-tDCS对认知功能和皮层活动的影响。
Slow wave sleep, hallmarked by the occurrence of slow oscillations (SO), plays an important role for the consolidation of hippocampus-dependent memories. Transcranial stimulation by weak electric currents oscillating at the endogenous SO frequency (SO-tDCS) during post-learning sleep was previously shown by us to boost SO activity and improve the consolidation of hippocampus-dependent memory in human subjects. Here, we aimed at replicating and extending these results to a rodent model. Rats were trained for 12 days at the beginning of their inactive phase in the reference memory version of the radial arm maze. In a between subjects design, animals received SO-tDCS over prefrontal cortex (PFC) or sham stimulation within a time frame of 1 h during subsequent non-rapid eye movement (NREM) sleep. Applied over multiple daily sessions SO-tDCS impacted cortical network activity as measured by EEG and behavior: at the EEG level, SO-tDCS enhanced post-stimulation upper delta (2–4 Hz) activity whereby the first stimulations of each day were preferentially affected. Furthermore, commencing on day 8, SO-tDCS acutely decreased theta activity indicating long-term effects on cortical networks. Behaviorally, working memory for baited maze arms was enhanced up to day 4, indicating enhanced consolidation of task-inherent rules, while reference memory errors did not differ between groups. Taken together, we could show here for the first time an effect of SO-tDCS during NREM sleep on cognitive functions and on cortical activity in a rodent model.
登录
查看更多内容
细胞外田地和电流的起源-EEG，ECOG，LFP和尖峰。
DOI：
10.1038/nrn3241
发表时间：
2012-05-18
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Buzsáki G;Anastassiou CA;Koch C
通讯作者：
Koch C
影响因子：
2.7
作者：
Dockery, Colleen A.;Liebetanz, David;Wesierska, Malgorzata J.
通讯作者：
Wesierska, Malgorzata J.
影响因子：
64.8
作者：
BINDMAN, LJ;LIPPOLD, OCJ;REDFEARN, JW
通讯作者：
REDFEARN, JW
影响因子：
3.3
作者：
Achermann, P;Borbely, AA
通讯作者：
Borbely, AA
DOI：
10.1523/jneurosci.2604-11.2011
发表时间：
2011-12-07
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Andrillon T;Nir Y;Staba RJ;Ferrarelli F;Cirelli C;Tononi G;Fried I
通讯作者：
Fried I