Body fat distribution, incident cardiovascular disease, cancer, and all-cause mortality.
Body fat distribution, incident cardiovascular disease, cancer, and all-cause mortality.
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DOI：
10.1016/j.jacc.2013.06.027
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发表时间：
2013-09-03
影响因子：
24
通讯作者：
Fox, Caroline S.
中科院分区：
文献类型：
--
作者：
Britton, Kathryn A.;Massaro, Joseph M.;Murabito, Joanne M.;Kreger, Bernard E.;Hoffmann, Udo;Fox, Caroline S.
确定异位脂肪沉积是否与心血管疾病、癌症和全因死亡率有前瞻性关联。与超重相关的发病率在体重指数相似的个体之间存在差异。异位脂肪库可能是这种风险差异的基础。然而，直接测量脂肪的前瞻性研究有限。来自心脏研究的参与者（n=3086，49%为女性，平均年龄50.2岁）使用多探测器计算机断层扫描对脂肪库（内脏脂肪组织、心包脂肪组织和主动脉周围脂肪组织）进行了评估，并纵向随访中位数为5.0年。考克斯比例风险回归模型用于检查每个脂肪储存（每1个标准差增量）与心血管疾病、癌症和校正标准风险因素（包括体重指数）后的全因死亡率风险的相关性。总的来说，有90起心血管事件，141起癌症事件和71起死亡。多变量校正后，内脏脂肪组织与心血管疾病（HR 1.44，95% CI 1.08-1.92，p=0.01）和癌症（HR 1.43，95% CI 1.12-1.84，p=0.005）相关。将内脏脂肪组织加入到包括体重指数的多变量模型中，适度改善了心血管风险预测（净重新分类改善16.3%）。没有一个脂肪库与全因死亡率相关。在调整临床危险因素和全身肥胖后，内脏肥胖与心血管疾病和癌症的发生有关。这些发现支持了异位脂肪致病作用的日益增长的升值。
To determine whether ectopic fat depots are prospectively associated with cardiovascular disease, cancer and all-cause mortality. The morbidity associated with excess body weight varies among individuals of similar body mass index. Ectopic fat depots may underlie this risk differential. However, prospective studies of directly measured fat are limited. Participants from the Framingham Heart Study (n=3086, 49% women, mean age 50.2 years) underwent assessment of fat depots (visceral adipose tissue, pericardial adipose tissue, and periaortic adipose tissue) using multidetector computed tomography, and were followed longitudinally for a median of 5.0 years. Cox proportional hazards regression models were used to examine the association of each fat depot (per 1 standard deviation increment) with the risk of incident cardiovascular disease, cancer, and all-cause mortality after adjustment for standard risk factors, including body mass index. Overall, there were 90 cardiovascular events, 141 cancer events, and 71 deaths. After multivariable adjustment, visceral adipose tissue was associated with cardiovascular disease (HR 1.44, 95% CI 1.08–1.92, p=0.01) and cancer (HR 1.43, 95% CI 1.12–1.84, p=0.005). Addition of visceral adipose tissue to a multivariable model that included body mass index modestly improved cardiovascular risk prediction (net reclassification improvement of 16.3%). None of the fat depots were associated with all-cause mortality. Visceral adiposity is associated with incident cardiovascular disease and cancer after adjustment for clinical risk factors and generalized adiposity. These findings support the growing appreciation of a pathogenic role of ectopic fat.
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炎症和代谢疾病中的脂肪因子。
DOI：
10.1038/nri2921
发表时间：
2011-02
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
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衡量心血管风险的个体预测因素的影响的进步：重新分类措施的作用。
影响因子：
39.2
作者：
Cook NR;Ridker PM
通讯作者：
Ridker PM
DOI：
10.1161/circimaging.110.958884
发表时间：
2010-09
期刊：
Circulation. Cardiovascular imaging
影响因子：
--
作者：
Fox CS;Massaro JM;Schlett CL;Lehman SJ;Meigs JB;O'Donnell CJ;Hoffmann U;Murabito JM
通讯作者：
Murabito JM
影响因子：
7.7
作者：
Hocking SL;Wu LE;Guilhaus M;Chisholm DJ;James DE
通讯作者：
James DE
影响因子：
7.1
作者：
Ding, Jingzhong;Hsu, Fang-Chi;Carr, J. Jeffrey
通讯作者：
Carr, J. Jeffrey