Amygdala projections to central amygdaloid nucleus subdivisions and transition zones in the primate.
Amygdala projections to central amygdaloid nucleus subdivisions and transition zones in the primate.
复制标题
DOI：
10.1016/j.neuroscience.2009.01.013
复制
发表时间：
2009-03-17
期刊：
影响因子：
3.3
通讯作者：
Tucker, T.
中科院分区：
文献类型：
--
作者：
Fudge, J. L.;Tucker, T.
关键词：
在大鼠和灵长类动物中，杏仁核中央核 (CeN) 因其在恐惧刺激反应中的作用而闻名。最近的证据还表明，当竞争刺激的显着性不断变化时，CeN 是引导注意力和行为所必需的。为了研究信息如何流经灵长类杏仁核的这个关键输出区域，我们首先将少量逆行示踪剂注射到中央核的细分中，并检查来自特定杏仁核的输入。使用组织化学标记将杏仁核纹状体区域和前连合后肢间质核 (IPAC) 与 CeN 区分开来，并且还描述了对这些区域的投影。正如预期的那样，基底核和副基底核是中央核和过渡区的主要传入连接。与外侧核心细分 (CeLcn) 相比，中央核的内侧细分 (CeM) 从所有区域接收到明显更强的输入。皮质杏仁样过渡区（内侧小细胞基底核、旁层核和沟周围杏仁核皮质的汇合区）为 CeLcn 提供主要输入。 IPAC和杏仁纹状体区域可分为内侧和外侧亚区域，并接收来自基底核和副基底核的输入，根据细分具有不同的输入。梨状皮层和外侧核是两个重要的感觉界面，将投射发送到过渡区。总之，CeM 从整个杏仁核接收广泛的输入，而 CeLcn 从相对未分化的皮质杏仁核过渡区域接收更有限的输入。与 CeN 一样，过渡区从基底核和副基底核接收大部分输入，然而，来自梨状皮层和外侧核的输入，以及缺乏来自小细胞副基底核的输入，是区别传入特征。
In rats and primates, the central nucleus of the amygdala (CeN) is most known for its role in responses to fear stimuli. Recent evidence also shows that the CeN is required for directing attention and behaviors when the salience of competing stimuli are in flux. To examine how information flows through this key output region of the primate amygdala, we first placed small injections of retrograde tracers into the subdivisions of the central nucleus and examined inputs from specific amygdaloid nuclei. The amygdalostriatal area and interstitial nucleus of the posterior limb of the anterior commissure (IPAC) were distinguished from the CeN using histochemical markers, and projections to these regions were also described. As expected, the basal nucleus and accessory basal nucleus are the main afferent connections of the central nucleus and transition zones. The medial subdivision of the central nucleus (CeM) receives a significantly stronger input from all regions compared to the lateral core subdivision (CeLcn). The corticoamygdaloid transition zone (a zone of confluence of the medial parvicellular basal nucleus, paralaminar nucleus, and the sulcal periamygdaloid cortex) provides the main input to the CeLcn. The IPAC and amygdalostriatal area can be divided in medial and lateral subregions, and receive input from the basal and accessory basal nucleus, with differential inputs according to subdivision. The pirifom cortex and lateral nucleus, two important sensory interfaces, send projections to the transition zones. In sum, the CeM receives broad inputs from the entire amygdala, whereas the CeLcn receives more restricted inputs from the relatively undifferentiated corticoamygdaloid transition region. Like the CeN, the transition zones receive most of their input from the basal nucleus and accessory basal nucleus, however, inputs from the piriform cortex and lateral nucleus, and a lack of input from the parvicellular accessory basal nucleus, are distinguishing afferent features.
登录
查看更多内容
影响因子：
2.5
作者：
BEALL, MJ;LEWIS, DA
通讯作者：
LEWIS, DA
影响因子：
5.7
作者：
Chua, P;Krams, M;Dolan, R
通讯作者：
Dolan, R
影响因子：
5.3
作者：
CAMPEAU, S;DAVIS, M
通讯作者：
DAVIS, M
影响因子：
3.4
作者：
Dumont, ÉC;Martina, M;Paré, D
通讯作者：
Paré, D
影响因子：
2.5
作者：
AGGLETON, JP;MISHKIN, M
通讯作者：
MISHKIN, M