Sucrose-predictive cues evoke greater phasic dopamine release than saccharin-predictive cues.
Sucrose-predictive cues evoke greater phasic dopamine release than saccharin-predictive cues.
复制标题
蔗糖预测线索比糖精预测线索引起更多的阶段性多巴胺释放。
DOI：
10.1002/syn.21519
复制
发表时间：
2012-04
期刊：
影响因子：
2.3
通讯作者：
Roitman, Mitchell F.
中科院分区：
文献类型：
--
作者：
McCutcheon, James E.;Beeler, Jeff A.;Roitman, Mitchell F.
与食物配对的暗示会激发伏隔核(NAC)中的多巴胺，并驱动接近行为。这种暗示引发的多巴胺信号可能会导致食物的过度消费。个人试图限制卡路里摄入量的一种方式是通过食用含有人造(非营养)甜味剂的食物。我们感兴趣的是，与非营养甜味剂(糖精)配对的信号是否会引起与营养甜味剂(蔗糖)配对的信号类似的多巴胺释放。我们训练限食大鼠将不同的线索与蔗糖或糖精颗粒联系起来。在第一组大鼠中，每个颗粒的训练课程在不同的日期进行，最大限度地增加了大鼠发现营养差异的机会。训练结束后，NAC核心的伏安记录显示，蔗糖线索比糖精线索引起更多的时相性多巴胺释放。在第二组大鼠中，在每个训练日，在同一时段内以伪随机顺序呈现蔗糖和糖精颗粒，以掩盖营养差异。在这种情况下，蔗糖和糖精之间的多巴胺差异会减弱，但不会消失。这些结果表明，与糖精配对的线索相比，蔗糖配对的线索将更有力地激励行为。对每个线索的不同反应似乎是由总体偏好驱动的，颗粒预测的营养价值以及其他因素，如味道，都起到了作用。
Cues that have been paired with food evoke dopamine in nucleus accumbens (NAc) and drive approach behavior. This cue-evoked dopamine signaling could contribute to overconsumption of food. One manner in which individuals try to restrict caloric intake is through the consumption of foods containing artificial (non-nutritive) sweeteners. We were interested in whether cues paired with a non-nutritive sweetener (saccharin) would evoke similar dopamine release as cues paired with a nutritive sweetener (sucrose). We trained food-restricted rats to associate distinct cues with sucrose or saccharin pellets. In the first group of rats, training sessions with each pellet took place on different days, maximizing the opportunity for rats to detect nutritional differences. After training, voltammetry recordings in NAc core revealed that sucrose cues evoked greater phasic dopamine release than saccharin cues. In a second group of rats, on each training day, sucrose and saccharin pellets were presented in pseudorandom order within the same session, to mask nutritional differences. In this condition, the difference in dopamine between sucrose and saccharin cues was attenuated, but not abolished. These results suggest that sucrose-paired cues will more powerfully motivate behavior than saccharin-paired cues. The differing responses to each cue seem to be driven by overall preference with both the nutritional value that the pellets predict as well as other factors, such as taste, contributing.
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影响因子：
64.8
作者：
Flagel SB;Clark JJ;Robinson TE;Mayo L;Czuj A;Willuhn I;Akers CA;Clinton SM;Phillips PE;Akil H
通讯作者：
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影响因子：
25
作者：
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粮食寻求食物的复发的神经药理学：方法论，主要发现和与寻求药物的复发的比较。
影响因子：
6.7
作者：
Nair SG;Adams-Deutsch T;Epstein DH;Shaham Y
通讯作者：
Shaham Y
影响因子：
10.6
作者：
Day, Jeremy J.;Jones, Joshua L.;Wightman, R. Mark;Carelli, Regina M.
通讯作者：
Carelli, Regina M.
DOI：
10.1126/science.1161550
发表时间：
2008-10-17
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Stice E;Spoor S;Bohon C;Small DM
通讯作者：
Small DM