Breathing coordinates cortico-hippocampal dynamics in mice during offline states.
Breathing coordinates cortico-hippocampal dynamics in mice during offline states.
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DOI：
10.1038/s41467-022-28090-5
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发表时间：
2022-01-24
影响因子：
16.6
通讯作者：
Sirota A
中科院分区：
文献类型：
--
作者：
Karalis N;Sirota A
网络动力学已被提出作为一个机械基板的信息传递皮层和海马电路。然而，人们对离线状态下在广泛的大脑区域同步和协调这些过程的机制知之甚少。在这里，我们解决的假设，呼吸作为一个振荡起搏器，持续耦合分布式脑回路动力学。使用大规模的记录，从一些皮层和皮层下的大脑区域的行为小鼠，我们发现存在一个脑内呼吸的必然放电，调节神经活动在这些电路。在离线状态下，呼吸调制是海马尖波波纹和皮质DOWN/UP状态转换耦合的基础，介导系统记忆巩固。这些结果强调了呼吸（一种常年的大脑节律）作为边缘回路功能协调的振荡支架，支持离线状态下神经元网络中信息流的分离和整合。使用行为小鼠的皮质和皮质下脑区域的大规模记录，作者揭示了小鼠呼吸必然放电的存在，该放电调节这些回路的神经活动，并耦合海马尖波波纹和皮质向下/向上状态转换。
Network dynamics have been proposed as a mechanistic substrate for the information transfer across cortical and hippocampal circuits. However, little is known about the mechanisms that synchronize and coordinate these processes across widespread brain regions during offline states. Here we address the hypothesis that breathing acts as an oscillatory pacemaker, persistently coupling distributed brain circuit dynamics. Using large-scale recordings from a number of cortical and subcortical brain regions in behaving mice, we uncover the presence of an intracerebral respiratory corollary discharge, that modulates neural activity across these circuits. During offline states, the respiratory modulation underlies the coupling of hippocampal sharp-wave ripples and cortical DOWN/UP state transitions, which mediates systems memory consolidation. These results highlight breathing, a perennial brain rhythm, as an oscillatory scaffold for the functional coordination of the limbic circuit that supports the segregation and integration of information flow across neuronal networks during offline states. Using large-scale recordings from cortical and subcortical brain regions in behaving mice, the authors reveal the presence of a respiratory corollary discharge in mice, that modulates neural activity across these circuits and couples hippocampal sharp-wave ripples and cortical DOWN/UP state transitions.
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影响因子：
16.2
作者：
Buzsáki G;Logothetis N;Singer W
通讯作者：
Singer W
影响因子：
2.6
作者：
Brown, RP;Gerbarg, PL
通讯作者：
Gerbarg, PL
DOI：
10.1016/0013-4694(50)90075-7
发表时间：
1950-01-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
ADRIAN, ED
通讯作者：
ADRIAN, ED
影响因子：
64.5
作者：
Chang RB;Strochlic DE;Williams EK;Umans BD;Liberles SD
通讯作者：
Liberles SD
影响因子：
5.5
作者：
Adrian, ED
通讯作者：
Adrian, ED