Material Engineering Platform for Next Generation of Neurobiological Interfaces.
Material Engineering Platform for Next Generation of Neurobiological Interfaces.
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DOI：
10.1021/accountsmr.0c00103
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发表时间：
2021-05-28
影响因子：
14.6
通讯作者：
Qiu J
中科院分区：
文献类型：
--
作者：
Rao S;Qiu J
神经生物学接口的工程创新为研究神经系统和进一步揭示神经和精神疾病背后的神经学原理提供了机会。界面上的信息交换将外部工程系统连接到内部生物机制。因此，神经生物学接口成为神经工程的重要工作场所。在神经生物学系统中，从细胞、神经回路到系统水平，信息流总是双向的，具有多种形式。为了探索最准确的神经回路机制，在自然行为的背景下调节和记录细胞神经动力学是必不可少的。这就为神经生物学接口的工程工具开发带来了巨大的挑战：解决自然功能神经系统内信息传递、处理和传播的复杂性，材料工程的进步加速了神经技术在多功能化、高集成度、生物安全性和可靠性方面的成熟。材料系统，从纳米级颗粒到微米级器件，已经成为通过各种方式探测神经生物学系统的必要中间体，例如基于光，电和化学信号的那些。例如，光学材料使我们能够将光传递到遗传修饰的光敏神经细胞，用于控制光遗传学中的神经活动，并收集荧光信号以解码光度和成像技术中的神经活动。电子材料的出现使从单细胞单位到大体积组织的神经电行为刺激和记录成为可能。此外，可以使用微流体神经探针在目标脑区域中诱导化学和遗传扰动，而可以使用原位电化学记录或微透析设置提取局部化学信息。神经生物学的进步极大地受益于材料-神经界面和相关工具的创新。
Engineering innovations at neurobiological interfaces open up the opportunities to investigate the nervous system and to further reveal the neurological principles underlying neurological and psychiatric disorders. The information exchange at the interfaces bridges the external engineering systems to the internal biological machineries. Therefore, the neurobiological interfaces become an important workplace for neural engineering. Across the neurobiological system from the cellular, the neural circuit and to the system level, information flow is always bidirectional with multiple modalities. To probe the most accurate neural circuitry mechanism, it is essential to modulate and record cellular neural dynamics in naturally behaving contexts. This leads to grand challenges for engineering tool development at the neurobiological interfaces: addressing the complexity of information delivery, processing, and dissemination within the naturally functioning nervous system.Material engineering advancements have accelerated the maturation of neural technologies in the perspectives of multifunctionalization, high-integration, biosafety, and reliability. Material systems, from nanoscale particles to microscale devices, have served as the essential intermediates to probe neurobiological systems via various modalities, such as those based on optical, electrical and chemical signals. For example, optical materials allow us to deliver light to genetically modified light-sensitive neural cells for controlling neural activity in optogenetics and collecting fluorescent signals to decode neural activities in photometric and imaging techniques. Electronic materials make it possible to stimulate and record neural electrical behaviors from single-cell unit to large-volume tissues. Moreover, chemical and genetic perturbations can be induced in targeted brain regions using microfluidic neural probes, while the local chemical information can be extracted using in situ electrochemical recordings or microdialysis setups. The advancement of neurobiology has benefited tremendously by the innovations of material-neural interfaces and related tools.
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影响因子：
4.6
作者：
Kampasi K;Stark E;Seymour J;Na K;Winful HG;Buzsáki G;Wise KD;Yoon E
通讯作者：
Yoon E
影响因子：
38.3
作者：
Rao, Siyuan;Chen, Ritchie;Anikeeva, Polina
通讯作者：
Anikeeva, Polina
影响因子：
19
作者：
Moon, Junsang;Christiansen, Michael G.;Anikeeva, Polina
通讯作者：
Anikeeva, Polina
影响因子：
56.9
作者：
Chen, Ritchie;Romero, Gabriela;Anikeeva, Polina
通讯作者：
Anikeeva, Polina
影响因子：
3.7
作者：
Guo, Yuanyuan;Werner, Carl F.;Yoshinobu, Tatsuo
通讯作者：
Yoshinobu, Tatsuo