Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups.
Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups.
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DOI：
10.1002/brb3.2413
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发表时间：
2022-01
影响因子：
3.1
通讯作者：
Morey RA
中科院分区：
文献类型：
--
作者：
Clausen AN;Fercho KA;Monsour M;Disner S;Salminen L;Haswell CC;Rubright EC;Watts AA;Buckley MN;Maron-Katz A;Sierk A;Manthey A;Suarez-Jimenez B;Olatunji BO;Averill CL;Hofmann D;Veltman DJ;Olson EA;Li G;Forster GL;Walter H;Fitzgerald J;Théberge J;Simons JS;Bomyea JA;Frijling JL;Krystal JH;Baker JT;Phan KL;Ressler K;Han LKM;Nawijn L;Lebois LAM;Schmaal L;Densmore M;Shenton ME;van Zuiden M;Stein M;Fani N;Simons RM;Neufeld RWJ;Lanius R;van Rooij S;Koch SBJ;Bonomo S;Jovanovic T;deRoon-Cassini T;Ely TD;Magnotta VA;He X;Abdallah CG;Etkin A;Schmahl C;Larson C;Rosso IM;Blackford JU;Stevens JS;Daniels JK;Herzog J;Kaufman ML;Olff M;Davidson RJ;Sponheim SR;Mueller SC;Straube T;Zhu X;Neria Y;Baugh LA;Cole JH;Thompson PM;Morey RA
创伤后应激障碍（PTSD）与加速衰老的标志物有关。与实际年龄相比，脑年龄的估计值可能会澄清PTSD对大脑的影响，并可能为针对PTSD背景下衰老神经生物学的治疗方法提供信息。来自21家ENIGMA-PGC PTSD研究中心的18-69岁（平均值= 35.6，SD = 11.0）成人受试者（N = 2229; 56.2%男性）接受了T1加权脑结构磁共振成像和PTSD评估（PTSD+，n = 884）。在对照受试者的子集（n = 386）中比较了先前训练的体素（brainageR）和感兴趣区域（BARACUS和PHOTON）机器学习管道。在全样本（有和没有PTSD）中进行线性混合效应模型，以检查PTSD对大脑预测年龄差异（大脑PAD;大脑年龄-实际年龄）的影响，控制实际年龄，性别和扫描部位。BrainageR最准确地预测了对照组（n = 386）的脑年龄（BrainageR：ICC = 0.71，R = 0.72，MAE = 5.68; PHOTON：ICC = 0.61，R = 0.62，MAE = 6.37; BARACUS：ICC = 0.47，R = 0.64，MAE = 8.80）。使用brainageR，一个三向相互作用显示，在年轻和老年组中，患有PTSD的年轻男性相对于男性对照组表现出更高的大脑PAD;与所有年龄段的男性对照组相比，患有PTSD的老年男性表现出更低的大脑PAD。PTSD对年轻男性和老年男性大脑PAD的不同影响可能表明PTSD影响大脑衰老的关键窗口，随后是与没有PTSD的个体一致的年龄相关的大脑变化。未来的纵向研究有必要了解PTSD如何影响整个生命周期的大脑衰老。创伤后应激障碍（PTSD）与加速衰老的标志物有关。我们探索了脑年龄的估计值，与实际年龄相比，作为PTSD人群加速老化的可能标志，利用大型多站点样本。我们确定了创伤后应激障碍，年龄和性别的相互作用，这表明年轻男性与创伤后应激障碍有更大的大脑预测年龄差异[PAD]比年轻男性对照组，年轻女性与创伤后应激障碍，年轻女性没有创伤后应激障碍。在中年男性中也存在类似的模式，但PTSD的影响比年轻人弱。老年亚组中的男性对照表现出比患有PTSD的老年男性、患有PTSD的老年女性和没有PTSD的老年女性更高的脑PAD。
Posttraumatic stress disorder (PTSD) is associated with markers of accelerated aging. Estimates of brain age, compared to chronological age, may clarify the effects of PTSD on the brain and may inform treatment approaches targeting the neurobiology of aging in the context of PTSD. Adult subjects (N = 2229; 56.2% male) aged 18–69 years (mean = 35.6, SD = 11.0) from 21 ENIGMA‐PGC PTSD sites underwent T1‐weighted brain structural magnetic resonance imaging, and PTSD assessment (PTSD+, n = 884). Previously trained voxel‐wise (brainageR) and region‐of‐interest (BARACUS and PHOTON) machine learning pipelines were compared in a subset of control subjects (n = 386). Linear mixed effects models were conducted in the full sample (those with and without PTSD) to examine the effect of PTSD on brain predicted age difference (brain PAD; brain age − chronological age) controlling for chronological age, sex, and scan site. BrainageR most accurately predicted brain age in a subset (n = 386) of controls (brainageR: ICC = 0.71, R = 0.72, MAE = 5.68; PHOTON: ICC = 0.61, R = 0.62, MAE = 6.37; BARACUS: ICC = 0.47, R = 0.64, MAE = 8.80). Using brainageR, a three‐way interaction revealed that young males with PTSD exhibited higher brain PAD relative to male controls in young and old age groups; old males with PTSD exhibited lower brain PAD compared to male controls of all ages. Differential impact of PTSD on brain PAD in younger versus older males may indicate a critical window when PTSD impacts brain aging, followed by age‐related brain changes that are consonant with individuals without PTSD. Future longitudinal research is warranted to understand how PTSD impacts brain aging across the lifespan. Posttraumatic stress disorder (PTSD) is associated with markers of accelerated aging. We explored estimates of brain age, as compared to chronological age, as a possible marker of accelerated aging in PTSD populations leveraging a large multi‐site sample. We identified an interaction of PTSD, age, and sex which showed young males with PTSD had a greater brain predicted age difference [PAD] than young male controls, young females with PTSD, and young females without PTSD. A similar pattern was present in middle‐aged males, but the effect of PTSD was weaker than in young adults. Male controls in the old subgroup exhibited higher brain‐PAD than old males with PTSD, old females with PTSD, and old females without PTSD.
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影响因子：
11
作者：
Elliott, Maxwell L.;Belsky, Daniel W.;Hariri, Ahmad R.
通讯作者：
Hariri, Ahmad R.
影响因子：
9.2
作者：
Brown, Timothy T.;Kuperman, Joshua M.;Chung, Yoonho;Erhart, Matthew;McCabe, Connor;Hagler, Donald J., Jr.;Venkatraman, Vijay K.;Akshoomoff, Natacha;Amaral, David G.;Bloss, Cinnamon S.;Casey, B. J.;Chang, Linda;Ernst, Thomas M.;Frazier, Jean A.;Gruen, Jeffrey R.;Kaufmann, Walter E.;Kenet, Tal;Kennedy, David N.;Murray, Sarah S.;Sowell, Elizabeth R.;Jernigan, Terry L.;Dale, Anders M.
通讯作者：
Dale, Anders M.
影响因子：
4.8
作者：
Bernstein, DP;Stein, JA;Zule, W
通讯作者：
Zule, W
影响因子：
--
作者：
Fotenos, Anthony F.;Mintun, Mark A.;Buckner, Randy L.
通讯作者：
Buckner, Randy L.
DOI：
10.1126/science.1194144
发表时间：
2010-09-10
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Dosenbach NU;Nardos B;Cohen AL;Fair DA;Power JD;Church JA;Nelson SM;Wig GS;Vogel AC;Lessov-Schlaggar CN;Barnes KA;Dubis JW;Feczko E;Coalson RS;Pruett JR Jr;Barch DM;Petersen SE;Schlaggar BL
通讯作者：
Schlaggar BL