PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice.
PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice.
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DOI：
10.1038/nn.2220
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发表时间：
2008-12
影响因子：
25
通讯作者：
Richardson, William D.
中科院分区：
文献类型：
--
作者：
Rivers, Leanne E.;Young, Kaylene M.;Rizzi, Matteo;Jamen, Francoise;Psachoulia, Konstantina;Wade, Anna;Kessaris, Nicoletta;Richardson, William D.
血小板源性生长因子α受体（PDGFRA）/NG 2表达神经胶质细胞分布在整个成年CNS。它们起源于围产期CNS中的少突胶质细胞前体（OLP），但尚不清楚它们是否在正常成年期继续产生髓鞘少突胶质细胞或其他分化细胞。我们跟踪了Pdgfra-creERT 2/Rosa 26-YFP双转基因小鼠中成年OLP的命运，发现它们在成年期产生了许多髓鞘形成的少突胶质细胞;成年小鼠胼胝体中所有少突胶质细胞的>20%在7周龄后产生，这引发了关于晚期髓鞘形成轴突功能的问题。OLP也在皮质中产生一些髓鞘形成细胞，但大多数成人出生的皮质细胞似乎没有髓鞘形成。我们没有发现星形胶质细胞在灰色或白色物质中产生的证据。然而，少数投射神经元产生于前脑，特别是在梨状皮质，这是嗅球的主要目标。
Platelet-derived growth factor α receptor (PDGFRA)/NG2–expressing glia are distributed throughout the adult CNS. They are descended from oligodendrocyte precursors (OLPs) in the perinatal CNS, but it is not clear whether they continue to generate myelinating oligodendrocytes or other differentiated cells during normal adult life. We followed the fates of adult OLPs in Pdgfra-creERT2/Rosa26-YFP double-transgenic mice and found that they generated many myelinating oligodendrocytes during adulthood; >20% of all oligodendrocytes in the adult mouse corpus callosum were generated after 7 weeks of age, raising questions about the function of the late-myelinating axons. OLPs also produced some myelinating cells in the cortex, but the majority of adult-born cortical cells did not appear to myelinate. We found no evidence for astrocyte production in gray or white matter. However, small numbers of projection neurons were generated in the forebrain, especially in the piriform cortex, which is the main target of the olfactory bulb.
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影响因子：
7.8
作者：
Aguirre, Adan A;Chittajallu, Ramesh;Belachew, Shibeshih;Gallo, Vittorio
通讯作者：
Gallo, Vittorio
影响因子：
64.8
作者：
Bergles, DE;Roberts, JDB;Jahr, CE
通讯作者：
Jahr, CE
DOI：
10.1023/a:1025751900356
发表时间：
2002-07-01
期刊：
JOURNAL OF NEUROCYTOLOGY
影响因子：
--
作者：
Butt, AM;Kiff, J;Berry, M
通讯作者：
Berry, M
影响因子：
56.9
作者：
Gould, E;Reeves, AJ;Gross, CG
通讯作者：
Gross, CG
影响因子：
64.8
作者：
FFRENCHCONSTANT, C;RAFF, MC
通讯作者：
RAFF, MC