MRI diffusion tensor tracking of a new amygdalo-fusiform and hippocampo-fusiform pathway system in humans.
MRI diffusion tensor tracking of a new amygdalo-fusiform and hippocampo-fusiform pathway system in humans.
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DOI：
10.1002/jmri.21692
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发表时间：
2009-06
影响因子：
4.4
通讯作者：
Conturo, Thomas E.
中科院分区：
文献类型：
--
作者：
Smith, Charles D.;Lori, Nicolas F.;Akbudak, Erbil;Sorar, Ertugrul;Gultepe, Eren;Shimony, Joshua S.;McKinstry, Robert C.;Conturo, Thomas E.
关键词：
目的：利用磁共振弥散张量追踪（DTT）技术检测人类梭状皮质中部与前内侧颞叶之间是否存在未知的神经纤维通路。假设存在这样的通路，因为这些区域在对具有情感价值的面孔和词语的功能性MRI（fMRI）研究中共同激活，这表明可以通过神经元连接介导的功能联系。使用无偏DTT方法研究了15名正常人受试者，该方法旨在探测未知的通路，包括全脑播种和大通路选择体积。几个质量控制步骤验证了结果。所有受试者的杏仁核-梭状和海马-梭状通路均平行存在。通路开始/结束于双侧外侧枕颞沟上方的梭状回中部。上级通路在上外侧杏仁核结束/开始。下方通路穿过内侧，在海马头部结束/开始。通路是左侧化的，具有一贯较大的横截面积、较高的各向异性和较低的左侧最小特征值（D-min），其中D-min评估与曲率无关的固有跨纤维扩散率。一个以前未描述的通路系统互连中梭状核区与杏仁核/海马体已被发现。这个通路系统可能对识别，记忆巩固和面部，物体和词汇信息的情绪调节很重要，这些信息可能在阿尔茨海默病等疾病中被破坏。
To use MRI diffusion-tensor tracking (DTT) to test for the presence of unknown neuronal fiber pathways interconnecting mid-fusiform cortex and anteromedial temporal lobe in humans. Such pathways are hypothesized to exist because these regions co-activate in functional MRI (fMRI) studies of emotion-valued faces and words, suggesting a functional link that could be mediated by neuronal connections. 15 normal human subjects were studied using unbiased DTT approaches designed for probing unknown pathways, including whole-brain seeding and large pathway-selection volumes. Several quality-control steps verified the results. Parallel amygdalo-fusiform and hippocampo-fusiform pathways were found in all subjects. The pathways begin/end at mid-fusiform gyrus above the lateral occipitotemporal sulcus bilaterally. The superior pathway ends/begins at the superolateral amygdala. The inferior pathway crosses medially and ends/begins at the hippocampal head. The pathways are left-lateralized, with consistently larger cross-sectional area, higher anisotropy, and lower minimum eigenvalue (D-min) on the left, where D-min assesses intrinsic cross-fiber diffusivity independent of curvature. A previously-undescribed pathway system interconnecting mid-fusiform region with amygdala/hippocampus has been revealed. This pathway system may be important for recognition, memory consolidation, and emotional modulation of face, object, and lexical information, which may be disrupted in conditions such as Alzheimer's disease.
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影响因子：
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