Immune signatures of protective spleen memory CD8 T cells.
Immune signatures of protective spleen memory CD8 T cells.
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DOI：
10.1038/srep37651
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发表时间：
2016-11-24
影响因子：
4.6
通讯作者：
Marvel J
中科院分区：
文献类型：
--
作者：
Brinza L;Djebali S;Tomkowiak M;Mafille J;Loiseau C;Jouve PE;de Bernard S;Buffat L;Lina B;Ottmann M;Rosa-Calatrava M;Schicklin S;Bonnefoy N;Lauvau G;Grau M;Wencker M;Arpin C;Walzer T;Leverrier Y;Marvel J
记忆性CD 8 T淋巴细胞群体是显著异质性的，并且在它们保护宿主的能力上不同。为了鉴定与保护性记忆细胞独特相关的全部性质，我们比较了具有相同抗原特异性的两种性质的记忆性CD 8 T细胞的基因表达特征：保护性（流感诱导的，Flu-TM）和非保护性（肽诱导的，TIM）脾记忆性CD 8 T细胞。尽管Flu-TM和TIM表达经典的表型记忆标记物并且是多功能的，但只有Flu-TM可以保护免受致命的病毒攻击。保护性记忆CD 8 T细胞表达参与迁移和存活的一组独特基因，这与它们响应流感感染在感染的肺实质内快速迁移的独特能力相关。我们还发现了一组新的由保护性细胞表达的稳定基因，这些基因强烈富集细胞因子和趋化因子，如Ccl 1，Ccl 9和Gm-CSF。CCL 1和GM-CSF基因也存在于人类记忆性CD 8 T细胞中。这些免疫特征也由另外两种病原体（牛痘病毒和单核细胞增生李斯特菌）诱导。在循环细胞上鉴定了与免疫保护相关的免疫特征，即易于获得免疫监测并可帮助预测疫苗效力的免疫特征。
Memory CD8 T lymphocyte populations are remarkably heterogeneous and differ in their ability to protect the host. In order to identify the whole range of qualities uniquely associated with protective memory cells we compared the gene expression signatures of two qualities of memory CD8 T cells sharing the same antigenic-specificity: protective (Influenza-induced, Flu-TM) and non-protective (peptide-induced, TIM) spleen memory CD8 T cells. Although Flu-TM and TIM express classical phenotypic memory markers and are polyfunctional, only Flu-TM protects against a lethal viral challenge. Protective memory CD8 T cells express a unique set of genes involved in migration and survival that correlate with their unique capacity to rapidly migrate within the infected lung parenchyma in response to influenza infection. We also enlighten a new set of poised genes expressed by protective cells that is strongly enriched in cytokines and chemokines such as Ccl1, Ccl9 and Gm-csf. CCL1 and GM-CSF genes are also poised in human memory CD8 T cells. These immune signatures are also induced by two other pathogens (vaccinia virus and Listeria monocytogenes). The immune signatures associated with immune protection were identified on circulating cells, i.e. those that are easily accessible for immuno-monitoring and could help predict vaccines efficacy.
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影响因子：
30.5
作者：
通讯作者：
--
影响因子：
64.5
作者：
Kaech, SM;Hemby, S;Ahmed, R
通讯作者：
Ahmed, R
DOI：
10.1084/jem.171.3.801
发表时间：
1990-03-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Mackay CR;Marston WL;Dudler L
通讯作者：
Dudler L
影响因子：
30.5
作者：
通讯作者：
--
影响因子：
12.3
作者：
Gentleman RC;Carey VJ;Bates DM;Bolstad B;Dettling M;Dudoit S;Ellis B;Gautier L;Ge Y;Gentry J;Hornik K;Hothorn T;Huber W;Iacus S;Irizarry R;Leisch F;Li C;Maechler M;Rossini AJ;Sawitzki G;Smith C;Smyth G;Tierney L;Yang JY;Zhang J
通讯作者：
Zhang J