Simultaneous decoupled detection of dopamine and oxygen using pyrolyzed carbon microarrays and fast-scan cyclic voltammetry.
Simultaneous decoupled detection of dopamine and oxygen using pyrolyzed carbon microarrays and fast-scan cyclic voltammetry.
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DOI：
10.1021/ac900790m
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发表时间：
2009-08-01
影响因子：
7.4
通讯作者：
McCarty, Gregory S.
中科院分区：
文献类型：
--
作者：
Zachek, Matthew K.;Takmakov, Pavel;Moody, Benjamin;Wightman, R. Mark;McCarty, Gregory S.
利用热解光致抗蚀剂的微细加工结构已被证明是监测电化学过程的有用工具。然而，这些先前的研究仅限于恒定电位测量和慢扫描伏安法。本报告中描述的工作利用微制造工艺来制造能够将多个快速扫描循环伏安法(FSCV)波形应用于单一衬底上的不同电极的器件。这使得同时检测多巴胺和氧气成为可能。本文描述了这些阵列的制备过程，并表明热解光刻胶电极具有与PAN型、T-650、碳纤维微电极相当的表面化学和电化学性能。根据响应于生理上相关浓度的多巴胺和氧气的流动注射的串扰程度来讨论阵列的功能。最后，展示了热解光致抗蚀剂微电极阵列的其他应用，包括：分析物的空间分辨检测以及将FSCV与安培法相结合用于检测多巴胺。
Microfabricated structures utilizing pyrolyzed photoresist have been shown to be a useful for monitoring electrochemical processes. These previous studies, however, were limited to constant potential measurements and slow scan voltammetry. Work described in this report utilizes microfabrication processes to produce devices that enable multiple fast-scan cyclic voltammetry (FSCV) waveforms to be applied to different electrodes on a single substrate. This enabled the simultaneous, decoupled, detection of dopamine and oxygen. This paper describes the fabrication process of these arrays and shows that pyrolyzed photoresist electrodes possess comparable surface chemistry and electrochemical properties to PAN type, T-650, carbon fiber microelectrodes using background-subtracted FSCV. The functionality of the array is discussed in terms of the degree of crosstalk in response to flow injections of physiologically relevant concentrations of dopamine and oxygen. Finally, other applications of pyrolyzed photoresist microelectrode arrays are shown, including: spatially resolved detection of analytes and combining FSCV with amperometry for the detection of dopamine.
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